Journal
CELLS
Volume 10, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/cells10040735
Keywords
dopamine; reward; motor control; synaptic plasticity; LTP; LTD; schizophrenia; Parkinson’ s disease; vascular dementia
Categories
Ask authors/readers for more resources
Dopamine is a key neurotransmitter involved in various physiological functions such as motor control, emotional regulation, reward mechanisms, and cognitive functions. Dysfunction in dopamine transmission is linked to devastating neurological and psychiatric disorders like Parkinson's disease and schizophrenia. Additionally, dopamine plays a crucial role in regulating synaptic dynamics, synaptic plasticity, and dendritic spines.
Dopamine (DA) is a key neurotransmitter involved in multiple physiological functions including motor control, modulation of affective and emotional states, reward mechanisms, reinforcement of behavior, and selected higher cognitive functions. Dysfunction in dopaminergic transmission is recognized as a core alteration in several devastating neurological and psychiatric disorders, including Parkinson's disease (PD), schizophrenia, bipolar disorder, attention deficit hyperactivity disorder (ADHD) and addiction. Here we will discuss the current insights on the role of DA in motor control and reward learning mechanisms and its involvement in the modulation of synaptic dynamics through different pathways. In particular, we will consider the role of DA as neuromodulator of two forms of synaptic plasticity, known as long-term potentiation (LTP) and long-term depression (LTD) in several cortical and subcortical areas. Finally, we will delineate how the effect of DA on dendritic spines places this molecule at the interface between the motor and the cognitive systems. Specifically, we will be focusing on PD, vascular dementia, and schizophrenia.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available