4.6 Review

Learning Yeast Genetics from Miro Radman

Journal

CELLS
Volume 10, Issue 4, Pages -

Publisher

MDPI
DOI: 10.3390/cells10040945

Keywords

Saccharomyces cerevisiae; budding yeast; mismatch repair; DNA damage response; SOS; homologous recombination; heteroduplex rejection

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Funding

  1. NIH [R35GM127029]

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Miroslav Radman's visionary ideas have had a significant impact on our study of the repair of broken eukaryotic chromosomes. For over 35 years, our lab has been investigating various aspects of chromosomal break repair in yeast, sometimes even advancing some of Radman's ideas further.
Miroslav Radman's far-sighted ideas have penetrated many aspects of our study of the repair of broken eukaryotic chromosomes. For over 35 years my lab has studied different aspects of the repair of chromosomal breaks in the budding yeast, Saccharomyces cerevisiae. From the start, we have made what we thought were novel observations that turned out to have been predicted by Miro's extraordinary work in the bacterium Escherichia coli and then later in the radiation-resistant Dienococcus radiodurans. In some cases, we have been able to extend some of his ideas a bit further.

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