Related references
Note: Only part of the references are listed.Repurposing old drugs as new inhibitors of the ubiquitin-proteasome pathway for cancer treatment
Huanjie Yang et al.
SEMINARS IN CANCER BIOLOGY (2021)
An ER-Targeting Iridium(III) Complex That Induces Immunogenic Cell Death in Non-Small-Cell Lung Cancer
Lili Wang et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)
被撤回的出版物: SOX2 Regulates lncRNA CCAT1/MicroRNA-185-3p/FOXP3 Axis to Affect the Proliferation and Self-Renewal of Cervical Cancer Stem Cells (Retracted article. See vol. 17, 2022)
Li Zhang et al.
NANOSCALE RESEARCH LETTERS (2021)
E1 Enzymes as Therapeutic Targets in Cancer
Samir H. Barghout et al.
PHARMACOLOGICAL REVIEWS (2021)
Recent insight into the role of FBXW7 as a tumor suppressor
Kanae Yumimoto et al.
SEMINARS IN CANCER BIOLOGY (2020)
BAP1: role in carcinogenesis and clinical implications
Daniel A. Kobrinski et al.
TRANSLATIONAL LUNG CANCER RESEARCH (2020)
Mesothelioma developing in carriers of inherited genetic mutations
Yoshie Yoshikawa et al.
TRANSLATIONAL LUNG CANCER RESEARCH (2020)
APC/C ubiquitin ligase: Functions and mechanisms in tumorigenesis
Morgan S. Schrock et al.
SEMINARS IN CANCER BIOLOGY (2020)
Clofarabine, cytarabine, and mitoxantrone in refractory/relapsed acute myeloid leukemia: High response rates and effective bridge to allogeneic hematopoietic stem cell transplantation
Harinder Gill et al.
CANCER MEDICINE (2020)
Drug Development Targeting the Ubiquitin-Proteasome System (UPS) for the Treatment of Human Cancers
Xiaonan Zhang et al.
CANCERS (2020)
Targeting MDM2 for Neuroblastoma Therapy: In Vitro and In Vivo Anticancer Activity and Mechanism of Action
Wei Wang et al.
CANCERS (2020)
IU1 suppresses proliferation of cervical cancer cells through MDM2 degradation
Liu Xu et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)
Preclinical studies reveal MLN4924 is a promising new retinoblastoma therapy
Arthur Aubry et al.
CELL DEATH DISCOVERY (2020)
UBE2C functions as a potential oncogene by enhancing cell proliferation, migration, invasion, and drug resistance in hepatocellular carcinoma cells
Yu Xiong et al.
BIOSCIENCE REPORTS (2019)
TP53 mutant cell lines selected for resistance to MDM2 inhibitors retain growth inhibition by MAPK pathway inhibitors but a reduced apoptotic response
Chiao-En Wu et al.
CANCER CELL INTERNATIONAL (2019)
UBE2S mediates tumor progression via SOX6/β-Catenin signaling in endometrial cancer
Meifang Lin et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2019)
CDC20 associated with cancer metastasis and novel mushroom-derived CDC20 inhibitors with antimetastatic activity
Shujie Cheng et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2019)
Mesothelioma: Scientific clues for prevention, diagnosis, and therapy
Michele Carbone et al.
CA-A CANCER JOURNAL FOR CLINICIANS (2019)
CDC20 expression in oestrogen receptor positive breast cancer predicts poor prognosis and lack of response to endocrine therapy
Lutfi H. Alfarsi et al.
BREAST CANCER RESEARCH AND TREATMENT (2019)
BAP1 regulates epigenetic switch from pluripotency to differentiation in developmental lineages giving rise to BAP1-mutant cancers
Jeffim N. Kuznetsov et al.
SCIENCE ADVANCES (2019)
BAP1 promotes stalled fork restart and cell survival via INO80 in response to replication stress
Han-Sae Lee et al.
BIOCHEMICAL JOURNAL (2019)
E2 ubiquitin-conjugating enzymes in cancer: Implications for immunotherapeutic interventions
Seyed Mohammad Hosseini et al.
CLINICA CHIMICA ACTA (2019)
The p97-Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8
Abhay Narayan Singh et al.
EMBO JOURNAL (2019)
Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis
Tao Han et al.
NATURE COMMUNICATIONS (2019)
A phase I study of the HDM2 antagonist SAR405838 combined with the MEK inhibitor pimasertib in patients with advanced solid tumours
Vincent A. de Weger et al.
BRITISH JOURNAL OF CANCER (2019)
Mutant p53 Sequestration of the MDM2 Acidic Domain Inhibits E3 Ligase Activity
Leixiang Yang et al.
MOLECULAR AND CELLULAR BIOLOGY (2019)
E6AP Promotes a Metastatic Phenotype in Prostate Cancer
Cristina Gamell et al.
ISCIENCE (2019)
A novel inhibitor of MDM2 oncogene blocks metastasis of hepatocellular carcinoma and overcomes chemoresistance
Wei Wang et al.
GENES & DISEASES (2019)
Ataxin-3 promotes testicular cancer cell proliferation by inhibiting anti-oncogene PTEN
Zhan Shi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)
UBE2S enhances the ubiquitination of p53 and exerts oncogenic activities in hepatocellular carcinoma
Ying-Hua Pan et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)
USP22 promotes resistance to EGFR-TKIs by preventing ubiquitination-mediated EGFR degradation in EGFR-mutant lung adenocarcinoma
Huijuan Zhang et al.
CANCER LETTERS (2018)
β-Trcp ubiquitin ligase and RSK2 kinase-mediated degradation of FOXN2 promotes tumorigenesis and radioresistance in lung cancer
Jia Ma et al.
CELL DEATH AND DIFFERENTIATION (2018)
USP7-TRIM27 axis negatively modulates antiviral type I IFN signaling
Juan Cai et al.
FASEB JOURNAL (2018)
Detecting germline BAP1 mutations in patients with peritoneal mesothelioma: benefits to patient and family members
Muaiad Kittaneh et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2018)
A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment
Marc L. Hyer et al.
NATURE MEDICINE (2018)
High expression of USP22 predicts poor prognosis and advanced clinicopathological features in solid tumors: a meta-analysis
Xiaohui Yang et al.
ONCOTARGETS AND THERAPY (2018)
A phase 1/2 study with birinapant in combination with pembrolizumab.
Russell J. Schilder et al.
JOURNAL OF CLINICAL ONCOLOGY (2018)
Frequency of Germline Mutations in Cancer Susceptibility Genes in Malignant Mesothelioma
Vasiliki Panou et al.
JOURNAL OF CLINICAL ONCOLOGY (2018)
FBXW7: a critical tumor suppressor of human cancers
Chien-Hung Yeh et al.
MOLECULAR CANCER (2018)
BAP1 links metabolic regulation of ferroptosis to tumour suppression
Yilei Zhang et al.
NATURE CELL BIOLOGY (2018)
The machineries, regulation and cellular functions of mitochondrial calcium
Carlotta Giorgi et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)
UBE2C Is a Potential Biomarker of Intestinal-Type Gastric Cancer With Chromosomal Instability
Jun Zhang et al.
FRONTIERS IN PHARMACOLOGY (2018)
被撤回的出版物: The miR 495-UBE2C-ABCG2/ERCC1 axis reverses cisplatin resistance by downregulating drug resistance genes in cisplatin-resistant non-small cell lung cancer cells (Retracted article. See vol. 63, 2021)
Jiwei Guo et al.
EBIOMEDICINE (2018)
UBE2S promotes the proliferation and survival of human lung adenocarcinoma cells
Zhi Liu et al.
BMB REPORTS (2018)
A phase I, open-label, multi-center, dose escalation study of oral NVP-CGM097, a p53/HDM2-protein-protein interaction inhibitor, in adult patients with selected advanced solid tumors
S. Bauer et al.
ANNALS OF ONCOLOGY (2017)
E6AP promotes prostate cancer by reducing p27 expression
Dinesh Raghu et al.
ONCOTARGET (2017)
Common, germline genetic variations in the novel tumor suppressor BAP1 and risk of developing different types of cancer
Moubin Lin et al.
ONCOTARGET (2017)
Intracellular protein degradation: From a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting
Aaron Ciechanover
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY (2017)
Defining a Cancer Dependency Map
Aviad Tsherniak et al.
CELL (2017)
Comprehensive review of BAP1 tumor predisposition syndrome with report of two new cases
K. Rai et al.
CLINICAL GENETICS (2016)
Abstract B27: A phase I dose escalation study of the MDM2 inhibitor DS-3032b in patients with advanced solid tumors and lymphomas
Todd Bauer et al.
MOLECULAR CANCER THERAPEUTICS (2016)
Overexpression of ubiquitin carboxyl terminal hydrolase-L1 enhances multidrug resistance and invasion/metastasis in breast cancer by activating the MAPK/Erk signaling pathway
Wenjuan Wang et al.
MOLECULAR CARCINOGENESIS (2016)
Inhibition of mTOR complex 2 induces GSK3/FBXW7-dependent degradation of sterol regulatory element-binding protein 1 (SREBP1) and suppresses lipogenesis in cancer cells
S. Li et al.
ONCOGENE (2016)
E2 enzymes: more than just middle men
Mikaela D. Stewart et al.
CELL RESEARCH (2016)
Stimulation of the Replication of ICP0-Null Mutant Herpes Simplex Virus 1 and pp71-Deficient Human Cytomegalovirus by Epstein-Barr Virus Tegument Protein BNRF1
Yongxu Lu et al.
JOURNAL OF VIROLOGY (2016)
Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53
Romain Riscal et al.
MOLECULAR CELL (2016)
Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22
Aidong Zhou et al.
NATURE CELL BIOLOGY (2016)
Restoration of tumor suppression in prostate cancer by targeting the E3 ligase E6AP
P. J. Paul et al.
ONCOGENE (2016)
Oncogenic mutations in the FBXW7 gene of adult T-cell leukemia patients
Chien-Hung Yeh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Regulating Fbw7 on the road to cancer
Wenshan Xu et al.
SEMINARS IN CANCER BIOLOGY (2016)
Ubiquitin-Dependent And Independent Signals In Selective Autophagy
Aliaksandr Khaminets et al.
TRENDS IN CELL BIOLOGY (2016)
De-ubiquitinating enzyme, USP11, promotes transforming growth factor β-1 signaling through stabilization of transforming growth factor β receptor II
A. M. Jacko et al.
CELL DEATH & DISEASE (2016)
Induction of cell proliferation, clonogenicity and cell accumulation in S phase as a consequence of human UBE2Q1 overexpression
Mohammad Ali Fahmidehkar et al.
ONCOLOGY LETTERS (2016)
A High-Density Map for Navigating the Human Polycomb Complexome
Simon Hauri et al.
CELL REPORTS (2016)
NeuCode Proteomics Reveals Bap1 Regulation of Metabolism
Joshua M. Baughman et al.
CELL REPORTS (2016)
Glioblastoma radiosensitization by pimozide
Barbara H. Rath et al.
TRANSLATIONAL CANCER RESEARCH (2016)
A phase 1 study of the MDM2 inhibitor DS-3032b in patients (pts) with advanced solid tumors and lymphomas.
Mrinal M. Gounder et al.
JOURNAL OF CLINICAL ONCOLOGY (2016)
UBE2Q1 in a Human Breast Carcinoma Cell Line: Overexpression and Interaction with p53
Sayed Mohammad Shafiee et al.
Asian Pacific Journal of Cancer Prevention (2015)
Targeting the ubiquitin pathway for cancer treatment
Jia Liu et al.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2015)
Phase I/II Study of Clofarabine, Etoposide, and Mitoxantrone in Patients With Refractory or Relapsed Acute Leukemia
Kamal K. S. Abbi et al.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA (2015)
Oral Debio 1143 (AT406), an Antagonist of Inhibitor of Apoptosis Proteins, Combined With Daunorubicin and Cytarabine in Patients With Poor-Risk Acute Myeloid Leukemia-Results of a Phase I Dose-Escalation Study
John F. DiPersio et al.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA (2015)
Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors
Philipp Holzer et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Carfilzomib, Lenalidomide, and Dexamethasone for Relapsed Multiple Myeloma
A. Keith Stewart et al.
NEW ENGLAND JOURNAL OF MEDICINE (2015)
Comparative Effectiveness of Mitoxantrone Plus Prednisone Versus Prednisone Alone in Metastatic Castrate-Resistant Prostate Cancer After Docetaxel Failure
Angela K. Green et al.
ONCOLOGIST (2015)
The demographics of the ubiquitin system
Michael J. Clague et al.
TRENDS IN CELL BIOLOGY (2015)
UBA1: At the Crossroads of Ubiquitin Homeostasis and Neurodegeneration
Ewout J. N. Groen et al.
TRENDS IN MOLECULAR MEDICINE (2015)
POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation
Boshi Wang et al.
NATURE COMMUNICATIONS (2015)
Ubiquitin C-terminal hydrolase-L1 increases cancer cell invasion by modulating hydrogen peroxide generated via NADPH oxidase 4
Hyun Jung Kim et al.
ONCOTARGET (2015)
Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1
Zhenghong Lin et al.
CELL DISCOVERY (2015)
Upregulated expression of ubiquitin-conjugating enzyme E2Q1 (UBE2Q1) is associated with enhanced cell proliferation and poor prognosis in human hapatocellular carcinoma
Renan Chang et al.
JOURNAL OF MOLECULAR HISTOLOGY (2015)
Germline Mutations in BAP1 Impair Its Function in DNA Double-Strand Break Repair
Ismail Hassan Ismail et al.
CANCER RESEARCH (2014)
Phase I Dose-Escalation Study of LCL161, an Oral Inhibitor of Apoptosis Proteins Inhibitor, in Patients With Advanced Solid Tumors
Jeffrey R. Infante et al.
JOURNAL OF CLINICAL ONCOLOGY (2014)
The role of Fbxw7 expression in hepatocellular carcinoma and adjacent non-tumor liver tissue
Satoru Imura et al.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014)
Targeting tumour-supportive cellular machineries in anticancer drug development
Matthias Dobbelstein et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair
Helen Yu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Post-translational modification networks regulating FOXP3 function
Jorg van Loosdregt et al.
TRENDS IN IMMUNOLOGY (2014)
Suppression of tumor angiogenesis by targeting the protein neddylation pathway
W-T Yao et al.
CELL DEATH & DISEASE (2014)
Stabilization and targeting of INO80 to replication forks by BAP1 during normal DNA synthesis
Han-Sae Lee et al.
NATURE COMMUNICATIONS (2014)
Germline BAP1 Mutations Predispose to Renal Cell Carcinomas
Tatiana Popova et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2013)
Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism
Jennifer L. Allensworth et al.
BREAST CANCER RESEARCH AND TREATMENT (2013)
Regulation of c-Myc Ubiquitination Controls Chronic Myelogenous Leukemia Initiation and Progression
Linsey Reavie et al.
CANCER CELL (2013)
Targeting the Ubiquitin-Mediated Proteasome Degradation of p53 for Cancer Therapy
Tiffany DeVine et al.
CURRENT PHARMACEUTICAL DESIGN (2013)
A Degrading View of Regulatory T Cells
Arian Laurence et al.
IMMUNITY (2013)
Mitoxantrone Targets Human Ubiquitin-Specific Peptidase 11 (USP11) and Is a Potent Inhibitor of Pancreatic Cancer Cell Survival
Richard A. Burkhart et al.
MOLECULAR CANCER RESEARCH (2013)
Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection
Andreas Kakarougkas et al.
NUCLEIC ACIDS RESEARCH (2013)
DEUBIQUITYLASES FROM GENES TO ORGANISM
Michael J. Clague et al.
PHYSIOLOGICAL REVIEWS (2013)
miR-29 Acts as a Decoy in Sarcomas to Protect the Tumor Suppressor A20 mRNA from Degradation by HuR
Mumtaz Yaseen Balkhi et al.
SCIENCE SIGNALING (2013)
Expression of UbcH10 in pancreatic ductal adenocarcinoma and its correlation with prognosis
Ze-Kun Zhao et al.
TUMOR BIOLOGY (2013)
IAP proteins as targets for drug development in oncology
Laurence Dubrez et al.
ONCOTARGETS AND THERAPY (2013)
Inhibition of ubiquitin conjugating enzyme UBE2C reduces proliferation and sensitizes breast cancer cells to radiation, doxorubicin, tamoxifen and letrozole
Akhilesh Rawat et al.
CELLULAR ONCOLOGY (2013)
SCFβ-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration
Jiateng Zhong et al.
ONCOTARGET (2013)
MDM2, MDMX and p53 in oncogenesis and cancer therapy
Mark Wade et al.
NATURE REVIEWS CANCER (2013)
Prognostic significance of UBE2C mRNA expression in high-risk early breast cancer. A Hellenic Cooperative Oncology Group (HeCOG) Study
A. Psyrri et al.
ANNALS OF ONCOLOGY (2012)
Inactivation of the Cullin (CUL)-RING E3 ligase by the NEDD8-activating enzyme inhibitor MLN4924 triggers protective autophagy in cancer cells
Zhongguang Luo et al.
AUTOPHAGY (2012)
Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A
Mary Pulvino et al.
BLOOD (2012)
A Small Molecule Inhibitor of Ubiquitin-Specific Protease-7 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Bortezomib Resistance
Dharminder Chauhan et al.
CANCER CELL (2012)
O-GlcNAc Transferase/Host Cell Factor C1 Complex Regulates Gluconeogenesis by Modulating PGC-1α Stability
Hai-Bin Ruan et al.
CELL METABOLISM (2012)
The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response
Laura R. Butler et al.
EMBO JOURNAL (2012)
Targeting neddylation in cancer therapy
Kristal Duncan et al.
FUTURE ONCOLOGY (2012)
Copy number loss of FBXW7 is related to gene expression and poor prognosis in esophageal squamous cell carcinoma
Takehiko Yokobori et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2012)
SCFβ-TRCP suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2
Shavali Shaik et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)
John A. Flygare et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
BAP1 cancer syndrome: malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs
Michele Carbone et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2012)
BAP1 loss defines a new class of renal cell carcinoma
Samuel Pena-LlopiS et al.
NATURE GENETICS (2012)
Germline BAP1 Inactivation Is Preferentially Associated with Metastatic Ocular Melanoma and Cutaneous-Ocular Melanoma Families
Ching-Ni Jenny Njauw et al.
PLOS ONE (2012)
MicroRNAs miR-125a and miR-125b constitutively activate the NF-κB pathway by targeting the tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20)
Sang-Woo Kim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
A Gatekeeper Residue for NEDD8-Activating Enzyme Inhibition by MLN4924
Julia I. Toth et al.
CELL REPORTS (2012)
K63-linked ubiquitination in kinase activation and cancer
Guocan Wang et al.
FRONTIERS IN ONCOLOGY (2012)
Selective and Cell-Active Inhibitors of the USP1/UAF1 Deubiquitinase Complex Reverse Cisplatin Resistance in Non-small Cell Lung Cancer Cells
Junjun Chen et al.
CHEMISTRY & BIOLOGY (2011)
In Vitro and In Vivo Selective Antitumor Activity of a Novel Orally Bioavailable Proteasome Inhibitor MLN9708 against Multiple Myeloma Cells
Dharminder Chauhan et al.
CLINICAL CANCER RESEARCH (2011)
Nonproteasomal Targets of the Proteasome Inhibitors Bortezomib and Carfilzomib: a Link to Clinical Adverse Events
Shirin Arastu-Kapur et al.
CLINICAL CANCER RESEARCH (2011)
Smac Mimetics Activate the E3 Ligase Activity of cIAP1 Protein by Promoting RING Domain Dimerization
Rebecca Feltham et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
A Potent and Orally Active Antagonist (SM-406/AT-406) of Multiple Inhibitor of Apoptosis Proteins (IAPs) in Clinical Development for Cancer Treatment
Qian Cai et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
The USP1/UAF1 Complex Promotes Double-Strand Break Repair through Homologous Recombination
Junko Murai et al.
MOLECULAR AND CELLULAR BIOLOGY (2011)
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
Ingrid E. Wertz et al.
NATURE (2011)
Germline BAP1 mutations predispose to malignant mesothelioma
Joseph R. Testa et al.
NATURE GENETICS (2011)
Inhibition of proteasome deubiquitinating activity as a new cancer therapy
Padraig D'Arcy et al.
NATURE MEDICINE (2011)
Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia
Ronan T. Swords et al.
BLOOD (2010)
Knockdown of human deubiquitinase PSMD14 induces cell cycle arrest and senescence
Ann Byrne et al.
EXPERIMENTAL CELL RESEARCH (2010)
Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer: clinical significance
Masaaki Iwatsuki et al.
INTERNATIONAL JOURNAL OF CANCER (2010)
Association of clinicopathological features with UbcH10 expression in colorectal cancer
Shimin Chen et al.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2010)
The Ubiquitin Carboxyl Hydrolase BAP1 Forms a Ternary Complex with YY1 and HCF-1 and Is a Critical Regulator of Gene Expression
Helen Yu et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
A20 is targeted by promoter methylation, deletion and inactivating mutation in MALT lymphoma
E. Chanudet et al.
LEUKEMIA (2010)
UCHL1 (PGP 9.5): Neuronal biomarker and ubiquitin system protein
Ian N. M. Day et al.
PROGRESS IN NEUROBIOLOGY (2010)
Frequent Mutation of BAP1 in Metastasizing Uveal Melanomas
J. William Harbour et al.
SCIENCE (2010)
The emerging complexity of protein ubiquitination
David Komander
BIOCHEMICAL SOCIETY TRANSACTIONS (2009)
The NF-κB negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas
Urban Novak et al.
BLOOD (2009)
Overexpression of UbcH10 alternates the cell cycle profile and accelerate the tumor proliferation in colon cancer
Takeo Fujita et al.
BMC CANCER (2009)
Comparative Proteomic Analysis of Osteosarcoma Cell and Human Primary Cultured Osteoblastic Cell
Xudong Liu et al.
CANCER INVESTIGATION (2009)
BRCA1-Associated Protein 1 Interferes with BRCA1/BARD1 RING Heterodimer Activity
Hiroyuki Nishikawa et al.
CANCER RESEARCH (2009)
Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling
Zhaoyu Jin et al.
CELL (2009)
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
Ji Luo et al.
CELL (2009)
Regulatory ubiquitylation in response to DNA double-strand breaks
Stephanie Panier et al.
DNA REPAIR (2009)
The Deubiquitinating Enzyme BAP1 Regulates Cell Growth via Interaction with HCF-1
Yuichi J. Machida et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
Teresa A. Soucy et al.
NATURE (2009)
Origin and function of ubiquitin-like proteins
Mark Hochstrasser
NATURE (2009)
Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways
Brenda A. Schulman et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Structural insights into NEDD8 activation of Cullin-RING ligases: Conformational control of conjugation
David M. Duda et al.
CELL (2008)
The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression
Xiao-Yong Zhang et al.
MOLECULAR CELL (2008)
The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization
Fatemeh Fouladkou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Bortezomib blocks Bax degradation in malignant B cells during treatment with TRAIL
Feng-Ting Liu et al.
BLOOD (2008)
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation
Markus Welcker et al.
NATURE REVIEWS CANCER (2008)
Human prostate cancer cells express neuroendocrine cell markers PGP 9.5 and chromogranin A
Aaron Leiblich et al.
PROSTATE (2007)
IAP antagonists induce autoubiquitination of c-IAPs, NF-κB activation, and TNFα-dependent apoptosis
Eugene Varfolomeev et al.
CELL (2007)
Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics
Yili Yang et al.
CANCER RESEARCH (2007)
FBXW7/hCDC4 is a general tumor suppressor in human cancer
Shahab Akhoondi et al.
CANCER RESEARCH (2007)
Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome
Susan D. Demo et al.
CANCER RESEARCH (2007)
Regulation of receptors and transporters by ubiquitination: New insights into surprisingly similar mechanisms
Manuel Miranda et al.
MOLECULAR INTERVENTIONS (2007)
Proteasome-independent functions of ubiquitin in endocytosis and signaling
Debdyuti Mukhopadhyay et al.
SCIENCE (2007)
Ubiquitination regulates PTEN nuclear import and tumor suppression
Lloyd C. Trotman et al.
CELL (2007)
NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN
Xinjiang Wang et al.
CELL (2007)
Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8)
George V. Avvakumov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Structural basis of ubiquitin recognition by the deubiquitinating protease USP2
Martin Renatus et al.
STRUCTURE (2006)
Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: Implications for the regulation of the p53-MDM2 pathway
M Hu et al.
PLOS BIOLOGY (2006)
A genomic and functional inventory of deubiquitinating enzymes
SMB Nijman et al.
CELL (2005)
Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14
M Hu et al.
EMBO JOURNAL (2005)
Deubiquitinating function of ataxin-3: Insights from the solution structure of the Josephin domain
Y Mao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas
P Pallante et al.
BRITISH JOURNAL OF CANCER (2005)
The solution structure of the Josephin domain of ataxin-3: Structural determinants for molecular recognition
G Nicastro et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Proteasome inhibitor therapy in multiple myeloma
D Chauhan et al.
MOLECULAR CANCER THERAPEUTICS (2005)
The development of proteasome inhibitors as anticancer drugs
J Adams
CANCER CELL (2004)
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
LT Vassilev et al.
SCIENCE (2004)
BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage
AR Schoenfeld et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Mechanism and function of deubiquitinating enzymes
AY Amerik et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2004)
The ubiquitin system: pathogenesis of human diseases and drug targeting
A Ciechanover et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2004)
Expression of protein gene product 9.5 (PGP9.5)/ubiquitin-C-terminal hydrolase 1 (UCHL-1) in human myeloma cells
T Otsuki et al.
BRITISH JOURNAL OF HAEMATOLOGY (2004)
Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors
XY Pei et al.
CLINICAL CANCER RESEARCH (2004)
A field guide to ubiquitylation
S Fang et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2004)
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7
M Yada et al.
EMBO JOURNAL (2004)
The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity
B Burnett et al.
HUMAN MOLECULAR GENETICS (2003)
The ubiquitin proteasome system in neurodegenerative diseases: Sometimes the chicken, sometimes the egg
A Ciechanover et al.
NEURON (2003)
Non-traditional functions of ubiquitin and ubiquitin-binding proteins
JD Schnell et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Protein profiling with Epstein-Barr nuclear antigen-1 reveals an interaction with the herpesvirus-associated ubiquitin-specific protease HAUSP/USP7
MN Holowaty et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Deubiquitinating enzymes as cellular regulators
JH Kim et al.
JOURNAL OF BIOCHEMISTRY (2003)
The proteasome: structure, function, and role in the cell
J Adams
CANCER TREATMENT REVIEWS (2003)
Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341
T Hideshima et al.
BLOOD (2003)
Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde
M Hu et al.
CELL (2002)
A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor I complex in Jurkat T cells
KL He et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization
MY Li et al.
NATURE (2002)
The ubiquitin-proteasome proteolytic pathway: Destruction for the sake of construction
MH Glickman et al.
PHYSIOLOGICAL REVIEWS (2002)
The proteasome regulates the UV-induced activation of the AP-1-like transcription factor Gcn4
ML Stitzel et al.
GENES & DEVELOPMENT (2001)
Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast
F Osaka et al.
EMBO JOURNAL (2000)
c-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover
F Bahram et al.
BLOOD (2000)