4.6 Review

Mouse Models for Deciphering the Impact of Homologous Recombination on Tumorigenesis

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination

Elsa Callen et al.

MOLECULAR CELL (2020)

Article Biochemistry & Molecular Biology

53BP1 loss rescues embryonic lethality but not genomic instability of BRCA1 total knockout mice

Jiyuan Chen et al.

CELL DEATH AND DIFFERENTIATION (2020)

Review Cell Biology

53BP1: a DSB escort

Zachary Mirman et al.

GENES & DEVELOPMENT (2020)

Review Cell Biology

The antitumorigenic roles of BRCA1-BARD1 in DNA repair and replication

Madalena Tarsounas et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Targeting dePARylation for cancer therapy

Muzaffer Ahmad Kassab et al.

CELL AND BIOSCIENCE (2020)

Article Biochemistry & Molecular Biology

BRCA1 Mutational Complementation Induces Synthetic Viability

Joseph Nacson et al.

MOLECULAR CELL (2020)

Article Biochemistry & Molecular Biology

Rad54 Drives ATP Hydrolysis-Dependent DNA Sequence Alignment during Homologous Recombination

J. Brooks Crickard et al.

Article Biochemistry & Molecular Biology

Regulation and pharmacological targeting of RAD51 in cancer

McKenzie K. Grundy et al.

NAR CANCER (2020)

Review Biochemistry & Molecular Biology

The BRCA Tumor Suppressor Network in Chromosome Damage Repair by Homologous Recombination

Weixing Zhao et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 88 (2019)

Article Biochemistry & Molecular Biology

BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation

Dali Zong et al.

MOLECULAR CELL (2019)

Review Cell Biology

Homologous Recombination and the Formation of Complex Genomic Rearrangements

Aurele Piazza et al.

TRENDS IN CELL BIOLOGY (2019)

Review Multidisciplinary Sciences

Emerging roles of eraser enzymes in the dynamic control of protein ADP-ribosylation

Julia O'Sullivan et al.

NATURE COMMUNICATIONS (2019)

Review Biochemistry & Molecular Biology

Shieldin - the protector of DNA ends

Dheva Setiaputra et al.

EMBO REPORTS (2019)

Article Cell Biology

Control of homologous recombination by the HROB-MCM8-MCM9 pathway

Nicole Hustedt et al.

GENES & DEVELOPMENT (2019)

Review Cell Biology

PARP Inhibitor Resistance: A Tug-of-War in BRCA-Mutated Cells

Sylvie M. Noordermeer et al.

TRENDS IN CELL BIOLOGY (2019)

Review Biochemistry & Molecular Biology

The Tumor Suppressor PALB2: Inside Out

Mandy Ducy et al.

TRENDS IN BIOCHEMICAL SCIENCES (2019)

Article Biochemistry & Molecular Biology

Disruption of Gen1 Causes Congenital Anomalies of the Kidney and Urinary Tract in Mice

Herui Wang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2018)

Review Biochemistry & Molecular Biology

Homologous recombination and the repair of DNA double-strand breaks

William Douglass Wright et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Multidisciplinary Sciences

Mechanism for survival of homozygous nonsense mutations in the tumor suppressor gene BRCA1

Aaron Seo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

The shieldin complex mediates 53BP1-dependent DNA repair

Sylvie M. Noordermeer et al.

NATURE (2018)

Article Multidisciplinary Sciences

Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination

Carla M. Abreu et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors

Manasi Ratnaparkhe et al.

NATURE COMMUNICATIONS (2018)

Review Genetics & Heredity

RAD-ical New Insights into RAD51 Regulation

Meghan R. Sullivan et al.

GENES (2018)

Article Oncology

Location of Mutation in BRCA2 Gene and Survival in Patients with Ovarian Cancer

S. Intidhar Labidi-Galy et al.

CLINICAL CANCER RESEARCH (2018)

Review Medicine, Research & Experimental

Genetically engineered mouse models in oncology research and cancer medicine

Kelly Kersten et al.

EMBO MOLECULAR MEDICINE (2017)

Review Biochemistry & Molecular Biology

Genomic rearrangements induced by unscheduled DNA double strand breaks in somatic mammalian cells

Ayeong So et al.

FEBS JOURNAL (2017)

Article Medicine, General & Internal

Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers

Karoline B. Kuchenbaecker et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2017)

Article Multidisciplinary Sciences

Loss of the homologous recombination gene rad51 leads to Fanconi anemia-like symptoms in zebrafish

Jan Gregor Botthof et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Biochemistry & Molecular Biology

Endogenous DNA Damage as a Source of Genomic Instability in Cancer

Anthony Tubbs et al.

Review Genetics & Heredity

Eukaryotic DNA Polymerases in Homologous Recombination

Mitch McVey et al.

ANNUAL REVIEW OF GENETICS, VOL 50 (2016)

Article Biochemistry & Molecular Biology

Gen1 and Eme1 Play Redundant Roles in DNA Repair and Meiotic Recombination in Mice

Xiaowen Wang et al.

DNA AND CELL BIOLOGY (2016)

Article Medicine, Research & Experimental

BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1

Rinske Drost et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Multidisciplinary Sciences

Replication fork stability confers chemoresistance in BRCA-deficient cells

Arnab Ray Chaudhuri et al.

NATURE (2016)

Article Genetics & Heredity

Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2

Suzanne A. Hartford et al.

PLOS GENETICS (2016)

Review Oncology

BRCAness revisited

Christopher J. Lord et al.

NATURE REVIEWS CANCER (2016)

Article Multidisciplinary Sciences

From Gene Targeting to Genome Editing: Transgenic animals applications and beyond

Mauricio Rocha-Martins et al.

ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS (2015)

Article Cell Biology

An Overview of the Molecular Mechanisms of Recombinational DNA Repair

Stephen C. Kowalczykowski

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)

Article Cell Biology

Meiotic Recombination: The Essence of Heredity

Neil Hunter

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)

Article Oncology

Biallelic Mutations in BRCA1 Cause a New Fanconi Anemia Subtype

Sarah L. Sawyer et al.

CANCER DISCOVERY (2015)

Article Biochemistry & Molecular Biology

Male Fertility Defect Associated with Disrupted BRCA1-PALB2 Interaction in Mice

Srilatha Simhadri et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Rad54 Functions as a Heteroduplex DNA Pump Modulated by Its DNA Substrates and Rad51 during D Loop Formation

William Douglass Wright et al.

MOLECULAR CELL (2014)

Article Biochemistry & Molecular Biology

Mouse SLX4 Is a Tumor Suppressor that Stimulates the Activity of the Nuclease XPF-ERCC1 in DNA Crosslink Repair

Michael R. G. Hodskinson et al.

MOLECULAR CELL (2014)

Article Medicine, General & Internal

Breast-Cancer Risk in Families with Mutations in PALB2

A. C. Antoniou et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Multidisciplinary Sciences

Role of BRCA1 in brain development

Gerald M. Pao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Cell Biology

The Dissolution of Double Holliday Junctions

Anna H. Bizard et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)

Review Genetics & Heredity

Is Non-Homologous End-Joining Really an Inherently Error-Prone Process?

Mireille Betermier et al.

PLOS GENETICS (2014)

Review Genetics & Heredity

Is homologous recombination really an error-free process?

Jose Guirouilh-Barbat et al.

FRONTIERS IN GENETICS (2014)

Review Oncology

Mouse models of BRCA1 and their application to breast cancer research

Jennifer Dine et al.

CANCER AND METASTASIS REVIEWS (2013)

Review Biochemistry & Molecular Biology

The Hallmarks of Aging

Carlos Lopez-Otin et al.

Article Genetics & Heredity

Germline RAD51C mutations in ovarian cancer susceptibility

F. Coulet et al.

CLINICAL GENETICS (2013)

Article Biochemistry & Molecular Biology

Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity

Weiqiang Lin et al.

EMBO JOURNAL (2013)

Article Biochemistry & Molecular Biology

Cooperative Control of Holliday Junction Resolution and DNA Repair by the SLX1 and MUS81-EME1 Nucleases

Dennis Castor et al.

MOLECULAR CELL (2013)

Article Multidisciplinary Sciences

HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis

Carrie A. Adelman et al.

NATURE (2013)

Article Multidisciplinary Sciences

Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer

Christian Bowman-Colin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Biotechnology & Applied Microbiology

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

Thomas Gaj et al.

TRENDS IN BIOTECHNOLOGY (2013)

Article Cell Biology

Repair of Strand Breaks by Homologous Recombination

Maria Jasin et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

Article Oncology

Biallelic Deleterious BRCA1 Mutations in a Woman with Early-Onset Ovarian Cancer

Susan M. Domchek et al.

CANCER DISCOVERY (2013)

Article Medicine, Research & Experimental

Molecular pathogenesis and clinical management of Fanconi anemia

Younghoon Kee et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Biochemistry & Molecular Biology

BRCA1 Functions Independently of Homologous Recombination in DNA Interstrand Crosslink Repair

Samuel F. Bunting et al.

MOLECULAR CELL (2012)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Article Multidisciplinary Sciences

Two classes of BRC repeats in BRCA2 promote RAD51 nucleoprotein filament function by distinct mechanisms

Aura Carreira et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Oncology

DNA interstrand crosslink repair and cancer

Andrew J. Deans et al.

NATURE REVIEWS CANCER (2011)

Article Biochemistry & Molecular Biology

Inactivation of Palb2 gene leads to mesoderm differentiation defect and early embryonic lethality in mice

Pia Rantakari et al.

HUMAN MOLECULAR GENETICS (2010)

Article Biotechnology & Applied Microbiology

Rad51C is essential for embryonic development and haploinsufficiency causes increased DNA damage sensitivity and genomic instability

Godelieve Smeenk et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2010)

Article Multidisciplinary Sciences

Purified human BRCA2 stimulates RAD51-mediated recombination

Ryan B. Jensen et al.

NATURE (2010)

Review Cell Biology

Genomic instability - an evolving hallmark of cancer

Simona Negrini et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA

Tina Thorslund et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)

Article Biochemistry & Molecular Biology

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

Peter Bouwman et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)

Review Oncology

Preclinical mouse models for BRCA1-associated breast cancer

R. M. Drost et al.

BRITISH JOURNAL OF CANCER (2009)

Article Biochemistry & Molecular Biology

The BRC Repeats of BRCA2 Modulate the DNA-Binding Selectivity of RAD51

Aura Carreira et al.

Article Biochemistry & Molecular Biology

PALB2 Links BRCA1 and BRCA2 in the DNA-Damage Response

Feng Zhang et al.

CURRENT BIOLOGY (2009)

Article Biochemistry & Molecular Biology

XRCC2 and XRCC3 Regulate the Balance between Short- and Long-Tract Gene Conversions between Sister Chromatids

Ganesh Nagaraju et al.

MOLECULAR AND CELLULAR BIOLOGY (2009)

Article Biotechnology & Applied Microbiology

Fanconi anemia and its diagnosis

Arleen D. Auerbach

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2009)

Article Biochemistry & Molecular Biology

Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells

Emilie Rass et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)

Article Multidisciplinary Sciences

DNA Polymerase δ Is Required for Early Mammalian Embryogenesis

Arikuni Uchimura et al.

PLOS ONE (2009)

Article Multidisciplinary Sciences

Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency

Pierre-Olivier Frappart et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

Shirley M. H. Sy et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends

Zhu Zhu et al.

Article Multidisciplinary Sciences

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

Eleni P. Mimitou et al.

NATURE (2008)

Article Multidisciplinary Sciences

The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression

Reena Shakya et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks

Latarsha J. Reid et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

Sven Rottenberg et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

Human CtIP promotes DNA end resection

Alessandro A. Sartori et al.

NATURE (2007)

Article Biochemistry & Molecular Biology

Rad54 dissociates homologous recombination intermediates by branch migration

Dmitry V. Bugreev et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)

Article Multidisciplinary Sciences

Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer

Xiaoling Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Biochemistry & Molecular Biology

BRCA2 is required for neurogenesis and suppression of medulloblastoma

Pierre-Olivier Frappart et al.

EMBO JOURNAL (2007)

Article Biochemistry & Molecular Biology

Differential regulation of short- and long-tract gene conversion between sister chromatids by Rad51C

Ganesh Nagaraju et al.

MOLECULAR AND CELLULAR BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Hyperplasia and spontaneous tumor development in the gynecologic system in mice lacking the BRCA1-Δ11 isoform

Sang Soo Kim et al.

MOLECULAR AND CELLULAR BIOLOGY (2006)

Article Cell Biology

BRCA1 ubiquitinates its phosphorylation-dependent binding partners CtIP

Xiaochun Yu et al.

GENES & DEVELOPMENT (2006)

Article Multidisciplinary Sciences

Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development

Kenji E. Orii et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2

Bing Xia et al.

MOLECULAR CELL (2006)

Article Biochemistry & Molecular Biology

Disruption of murine Mus81 increases genomic instability and DNA damage sensitivity but does not promote tumorigenesis

N Dendouga et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis haploid insufficiency

PL Chen et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Article Multidisciplinary Sciences

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

J Bartkova et al.

NATURE (2005)

Article Multidisciplinary Sciences

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

H Farmer et al.

NATURE (2005)

Article Biochemistry & Molecular Biology

A delayed chemically induced tumorigenesis in Brca2 mutant mice

DH Yan et al.

ONCOGENE (2004)

Review Biochemistry & Molecular Biology

Unraveling V(D)J recombination: Insights into gene regulation

D Jung et al.

Article Multidisciplinary Sciences

Involvement of mammalian Mus81 in genome integrity and tumor suppression

JP McPherson et al.

SCIENCE (2004)

Article Biochemistry & Molecular Biology

An essential role of DmRad51/SpnA in DNA repair and meiotic checkpoint control

E Staeva-Vieira et al.

EMBO JOURNAL (2003)

Article Oncology

Shared genetic susceptibility to breast cancer, brain tumors, and Fanconi anemia

K Offit et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2003)

Article Biochemistry & Molecular Biology

Homologous DNA pairing by human recombination factors Rad51 and Rad54

S Sigurdsson et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Multidisciplinary Sciences

Biallelic inactivation of BRCA2 in Fanconi anemia

NG Howlett et al.

SCIENCE (2002)

Article Biochemistry & Molecular Biology

Characterization of homologous recombination induced by replication inhibition in mammalian cells

Y Saintigny et al.

EMBO JOURNAL (2001)

Article Cell Biology

Tumorigenesis in mice carrying a truncating Brca1 mutation

T Ludwig et al.

GENES & DEVELOPMENT (2001)

Article Genetics & Heredity

Variation in cancer risks, by mutation position, in BRCA2 mutation carriers

D Thompson et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2001)

Article Biochemistry & Molecular Biology

Xrcc2 is required for genetic stability, embryonic neurogenesis and viability in mice

B Deans et al.

EMBO JOURNAL (2000)

Article Biochemistry & Molecular Biology

Rad54 protein is targeted to pairing loci by the Rad51 nucleoprotein filament

AV Mazin et al.

MOLECULAR CELL (2000)