Predictive and Prognostic Value of Microsatellite Instability in Gynecologic Cancer (Endometrial and Ovarian)

Simple Summary Endometrial cancers are the cancers most affected by microsatellite instability. This phenotype confers a demonstrated sensitivity to immunotherapy and in this sense is a major parameter to know in order to manage patients. Molecular biology, therefore, has an essential role in the better knowledge of these endometrial tumors. Moreover, the microsatellite instability phenotype is very poorly understood in ovarian cancer, yet it does exist. We therefore present here a review of the literature concerning microsatellite instability in gynecological cancers (endometrium and ovaries): its diagnosis, its clinical characteristics, and its therapeutic and prognostic impact. For endometrial cancer, a new classification is now available from ESMO, ESGO, and ESTRO based on clinical and molecular characteristics to determine adjuvant therapy. The contribution of molecular biology is major for this pathology mainly by the intermediary of deficient mismatch repair/microsatellite instability. Detection techniques for this phenotype have many peculiarities in gynecologic cancers (endometrial and ovarian) because it has been initially validated in colorectal cancer only. Endometrial cancer is the most common tumor with deficient mismatch repair, which is an important prognostic factor and a predictor of the benefit of adjuvant treatments. Concerning advanced stages, this phenotype is a theragnostic marker for using immunotherapy. Among ovarian cancer, microsatellite instability is less described in literature but exists, particularly in endometrioid type ovarian cancer. This review aims to provide an overview of the publications concerning deficient mismatch repair/microsatellite instability in endometrial and ovarian cancers, detection techniques, and clinical implications of these molecular characteristics.

Automated summary

Endometrial cancers are highly affected by microsatellite instability, showing sensitivity to immunotherapy and requiring molecular biology for better understanding. The phenotype is poorly understood in ovarian cancer but does exist. Examination of literature reveals the importance of deficient mismatch repair/microsatellite instability in gynecological cancers and the potential therapeutic and prognostic implications.