Journal
JOURNAL OF CLINICAL MEDICINE
Volume 10, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/jcm10092019
Keywords
neuroendocrine; larynx; squamous; poorly differentiated; carcinoma; miRNA
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Funding
- POR Campania FESR [FSN 2014-2015-2016 Linea 5/11]
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Laryngeal neuroendocrine carcinomas are rare and heterogeneous malignancies. A retrospective study of ten patients showed that miRNA study revealed a specific signature related to poorly differentiated tumors. These findings may improve diagnosis and treatment outcomes for this aggressive neoplasm.
Laryngeal neuroendocrine carcinomas (LNECs) are rare and highly heterogeneous malignancies presenting a wide range of pathological and clinical manifestations. Herein, we retrospectively characterize ten patients diagnosticated with LNEC, five of which were defined as well-moderately differentiated neuroendocrine carcinomas, and five that were defined as poorly differentiated neuroendocrine carcinomas, according to the latest WHO classification. Clinical features were analyzed and compared between the two subgroups together with a microRNA study which evidenced a peculiar signature likely related to poorly differentiated larynx neuroendocrine carcinomas. These findings may offer new useful insights for clinicians to improve diagnosis efficiency, therapy response, and patients' outcome for this aggressive neoplasm.
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