Journal
JOURNAL OF CLINICAL MEDICINE
Volume 10, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/jcm10091874
Keywords
sepsis; myopathy; acute muscle wasting
Categories
Funding
- National Institute of General Medical Sciences (NIGMS) [P50 GM-111152, R01GM118895-0, P30 AG028740]
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Sepsis survivors often experience persistent myopathy characterized by skeletal muscle weakness, atrophy, and the inability to repair damaged myofibers. The origins of this myopathy are likely complex, involving interactions between impaired muscle metabolism and circulating pathogens. Physical inactivity during hospitalization may exacerbate the myopathy, highlighting the potential role of physical rehabilitation in preventing decline in physical function for septic patients.
Sepsis survivors experience a persistent myopathy characterized by skeletal muscle weakness, atrophy, and an inability to repair/regenerate damaged or dysfunctional myofibers. The origins and mechanisms of this persistent sepsis-induced myopathy are likely complex and multifactorial. Nevertheless, the pathobiology is thought to be triggered by the interaction between circulating pathogens and impaired muscle metabolic status. In addition, while in the hospital, septic patients often experience prolonged periods of physical inactivity due to bed rest, which may exacerbate the myopathy. Physical rehabilitation emerges as a potential tool to prevent the decline in physical function in septic patients. Currently, there is no consensus regarding effective rehabilitation strategies for sepsis-induced myopathy. The optimal timing to initiate the rehabilitation intervention currently lacks consensus as well. In this review, we summarize the evidence on the fundamental pathobiological mechanisms of sepsis-induced myopathy and discuss the recent evidence on in-hospital and post-discharge rehabilitation as well as other potential interventions that may prevent physical disability and death of sepsis survivors.
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