Oxidative Stress and Endoplasmic Reticulum Stress in Rare Respiratory Diseases

Several studies have shown that some rare respiratory diseases, such as alpha-1 antitrypsin deficiency (AATD), idiopathic pulmonary fibrosis (IPF), cystic fibrosis (CF), and primary ciliary dyskinesia (PCD) present oxidative stress (OS) and endoplasmic reticulum (ER) stress. Their involvement in these pathologies and the use of antioxidants as therapeutic agents to minimize the effects of OS are discussed in this review.

Automated summary

Rare respiratory diseases like AATD, IPF, CF, and PCD have been shown to exhibit oxidative stress and endoplasmic reticulum stress. This review discusses their involvement in the pathologies and the potential use of antioxidants as therapeutic agents to mitigate the effects of oxidative stress.