4.7 Review

Understanding Why Post-Stroke Depression May Be the Norm Rather Than the Exception: The Anatomical and Neuroinflammatory Correlates of Post-Stroke Depression

Journal

JOURNAL OF CLINICAL MEDICINE
Volume 10, Issue 8, Pages -

Publisher

MDPI
DOI: 10.3390/jcm10081674

Keywords

cytokine; depression; ischemia; stroke; apoptosis; excitotoxicity; oncosis; inflammation

Funding

  1. Monash Medical School and Migraine Foundation

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The study analyzed the inflammatory basis of post-stroke depression, which results in cell death, persistent neuro-inflammation, and disrupted neuronal networks in mood-related brain regions. Furthermore, the anatomical structures related to post-stroke depression may involve complex circuitries in cortical and subcortical regions.
Ischemic Stroke precedes depression. Post-stroke depression (PSD) is a major driver for poor recovery, negative quality of life, poor rehabilitation outcomes and poor functional ability. In this systematic review, we analysed the inflammatory basis of post-stroke depression, which involves bioenergetic failure, deranged iron homeostasis (calcium influx, Na influx, potassium efflux etc), excitotoxicity, acidotoxicity, disruption of the blood brain barrier, cytokine-mediated cytotoxicity, reactive oxygen mediated toxicity, activation of cyclooxygenase pathway and generation of toxic products. This process subsequently results in cell death, maladapted, persistent neuro-inflammation and deranged neuronal networks in mood-related brain regions. Furthermore, an in-depth review likewise reveals that anatomic structures related to post-stroke depression may be localized to complex circuitries involving the cortical and subcortical regions.

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