Journal
JOURNAL OF CLINICAL MEDICINE
Volume 10, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/jcm10081771
Keywords
COVID-19; juvenile idiopathic arthritis; disease-modifying antirheumatic drugs; SARS-CoV-2
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Funding
- Medical University of Lublin [DS410, DS460]
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This study investigated the prevalence of anti-SARS-CoV-2 antibodies in children with juvenile idiopathic arthritis (JIA) and found no clear correlation between the presence of these antibodies and disease activity. Additionally, a possible link between patients' humoral immune response and disease-modifying antirheumatic treatment was identified, which requires confirmation in follow-up studies.
There is limited data on the effect of the novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) on pediatric rheumatology. We examined the prevalence of antibodies against SARS-CoV-2 in children with juvenile idiopathic arthritis (JIA) and a negative history of COVID-19 and the correlation of the presence of these antibodies with disease activity measured by juvenile arthritis disease activity score (JADAS). In total, 62 patients diagnosed with JIA, under treatment with various antirheumatic drugs, and 32 healthy children (control group) were included. Serum samples were analyzed for inflammatory markers and antibodies and their state evaluated with the juvenile arthritis disease activity score (JADAS). JIA patients do not have a higher seroprevalence of anti-SARS-CoV-2 antibodies than healthy subjects. We found anti-SARS-CoV-2 antibodies in JIA patients who did not have a history of COVID-19. The study showed no unequivocal correlation between the presence of SARS-CoV-2 antibodies and JIA activity; therefore, this relationship requires further observation. We also identified a possible link between patients' humoral immune response and disease-modifying antirheumatic treatment, which will be confirmed in follow-up studies.
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