4.8 Article

Discovery of a natural cyan blue: A unique food-sourced anthocyanin could replace synthetic brilliant blue

Journal

SCIENCE ADVANCES
Volume 7, Issue 15, Pages -

Publisher

AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abe7871

Keywords

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Funding

  1. EU [676598, 824143]
  2. University of California Davis, Innovation Institute for Food and Health at UC Davis
  3. U.S. NIH [R01 GM 076324-11]
  4. NSF [1827246, 1805510, 1627539]
  5. National Institute of Environmental Health Sciences (NIEHS) of the NIH [P42ES004699]
  6. Directorate For Engineering
  7. Div Of Chem, Bioeng, Env, & Transp Sys [1805510] Funding Source: National Science Foundation

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The color of food plays a critical role in the food and beverage industries, with blue being one of the rarest colors in natural food. Finding a natural blue food colorant remains a challenge for the global food industry, and a multidisciplinary approach has been demonstrated to be powerful in addressing this issue.
The color of food is critical to the food and beverage industries, as it influences many properties beyond eye-pleasing visuals including flavor, safety, and nutritional value. Blue is one of the rarest colors in nature's food palette-specially a cyan blue-giving scientists few sources for natural blue food colorants. Finding a natural cyan blue dye equivalent to FD&C Blue No. 1 remains an industry-wide challenge and the subject of several research programs worldwide. Computational simulations and large-array spectroscopic techniques were used to determine the 3D chemical structure, color expression, and stability of this previously uncharacterized cyan blue anthocyanin-based colorant. Synthetic biology and computational protein design tools were leveraged to develop an enzymatic transformation of red cabbage anthocyanins into the desired anthocyanin. More broadly, this research demonstrates the power of a multidisciplinary strategy to solve a long-standing challenge in the food industry.

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