Transfer hydroarylation of ketones using directing-group-free, unstrained alcohols

In this issue of Chem, Morandi and coworkers report an exciting reversible transfer hydroarylation between ketones and unstrained arylated alcohols. Through a Rh-catalyzed beta-aryl elimination process, the aryl moiety shuttles'' from the alcohol to the ketone substrate, which provides a milder alternative to conventional Grignard and organolithium addition chemistry.

Automated summary

In this issue of Chem, Morandi and coworkers describe an exciting reversible transfer hydroarylation reaction between ketones and unstrained arylated alcohols. The reaction involves a Rh-catalyzed beta-aryl elimination process, allowing for the transfer of an aryl group from the alcohol to the ketone substrate and providing a milder alternative to conventional Grignard and organolithium addition chemistry.