4.8 Editorial Material

COVID-19 highlights the model dilemma in biomedical research

Journal

NATURE REVIEWS MATERIALS
Volume 6, Issue 5, Pages 374-376

Publisher

NATURE PORTFOLIO
DOI: 10.1038/s41578-021-00305-z

Keywords

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Funding

  1. Faculty of Pharmaceutical Sciences at the University of British Columbia
  2. Canadian Institutes of Health Research [CIHR PJT-166035]
  3. Natural Sciences and Engineering Research Council Canada (NSERC) [RGPIN-2020-04224]
  4. John R. Evans Leaders Fund
  5. German Federal Ministry of Education and Research, Netzwerk Universitatsmedizin, Organo-Strat COVID-19
  6. collaborative research centre by the German Research Foundation [SFB-TR84]

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Scientists globally face challenges in finding appropriate animal models for studying SARS-CoV-2 infections due to interspecies-related differences, but human-based models like micro-engineered multi-organs-on-chip may provide a solution.
Scientists worldwide struggle to identify suitable animal models to study SARS-CoV-2 infections. Interspecies-related differences, such as host specificity, divergent immune responses, or the unavailability of species-specific reagents hamper the research. Human-based models, such as micro-engineered multi-organs-on-chip, may hold the solution.

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