Journal
HLA
Volume 98, Issue 1, Pages 37-42Publisher
WILEY
DOI: 10.1111/tan.14256
Keywords
association; coronavirus disease 2019; human leukocyte antigen; Japan; risk factor; severe acute respiratory syndrome coronavirus 2
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology [18H02514, 19H05341]
- Japan Agency for Medical Research and Development [JP19fk0108104j0801, JP20he0622022j0201]
- Ministry of Education
- Grants-in-Aid for Scientific Research [18H02514, 19H05341] Funding Source: KAKEN
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The study found a significant association between the HLA-DRB1*09:01 allele and severe COVID-19, with a higher risk compared to preexisting medical conditions such as hypertension, diabetes, and cardiovascular diseases. These results suggest a potential role for HLA in predisposing individuals to severe COVID-19.
HLA-A, -C, -B, and -DRB1 genotypes were analyzed in 178 Japanese COVID-19 patients to investigate the association of HLA with severe COVID-19. Analysis of 32 common HLA alleles at four loci revealed a significant association between HLA-DRB1*09:01 and severe COVID-19 (odds ratio [OR], 3.62; 95% CI, 1.57-8.35; p = 0.00251 [permutation p value = 0.0418]) when age, sex, and other common HLA alleles at the DRB1 locus were adjusted. The DRB1*09:01 allele was more significantly associated with risk for severe COVID-19 compared to preexisting medical conditions such as hypertension, diabetes, and cardiovascular diseases. These results indicate a potential role for HLA in predisposition to severe COVID-19.
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