Microwave-Assisted Green Synthesis of 2,3-Dihydroquinazolinones under Base- and Catalyst-Free conditions

A facile and green one-pot synthesis of 2,3-dihydroquinazolinones, using microwave irradiation, has been developed. Dihydroquinazolinones were synthesized from 2-aminobenzamide derivatives and various aldehydes in aqueous solution under base and catalyst free reaction conditions. The desired products, from aliphatic and aromatic aldehydes substrates, were obtained in 5 minutes with up to 99 % isolated yields.

Automated summary

A facile and green one-pot synthesis of 2,3-dihydroquinazolinones using microwave irradiation has been developed. The desired products can be obtained in 5 minutes with up to 99% isolated yields from aliphatic and aromatic aldehydes substrates under base and catalyst free reaction conditions.