Journal
CHEMISTRYSELECT
Volume 6, Issue 18, Pages 4539-4543Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202101029
Keywords
Cascade reaction; Furocoumarins; Lewis acid; Multicomponent reactions ⋅ Synthesis design
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Funding
- provincial planning project of Zhejiang provincial science and technology department [LGF19B060005]
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A concise one-pot route for the synthesis of furo[3,2-c]-coumarins catalyzed by Zn(OTf)(2) has been reported, allowing for the easy generation of libraries of furocoumarin analogues through multicomponent tandem reactions. This transformation is highly atom economical and exhibits good functional group compatibility.
A concise, one-pot route for the synthesis of furo[3,2-c]-coumarins under the catalysis of Zn(OTf)(2) is reported. Utilizing this synthetic strategy, libraries of furocoumarin analogues can be easily obtained by multicomponent tandem reactions with different nucleophile in the presence of 4-hydroxycoumarin and arylglyoxal monohydrate system, This transformation exhibited highly atom economical and good functional group compatibility.
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