Journal
FRONTIERS IN ENDOCRINOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2020.519923
Keywords
cardiovascular diseases; amino acids; metabolism; type 2 diabetes; Chinese
Categories
Funding
- project for the National Key Research and Development Program of China [2019YFA0802300]
- 13th five year plan and TMU talent project [11601501, 2016KJ0313]
- National Natural Science Foundation of China [81602826, 81672961]
- China Postdoctoral Science Foundation [2016M590210, 2017T100164]
- Tianjin Health Bureau Science Foundation Key Project [16KG154]
- Tianjin Project of Thousand Youth Talents, Key Laboratory Open Project Fund from State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences [KF2017]
- Postgraduate Innovation Fund of 13th Five-Year comprehensive investment, Tianjin Medical University [YJSCX201816]
- Open Project of the Key Laboratory of Modern Toxicology of Ministry of Education, Nanjing Medical University [NMUMT201809]
Ask authors/readers for more resources
This study found that elevated factor 3 composed of glutamate and tryptophan in plasma free amino acids was associated with increased risk of cardiovascular disease, especially stroke, in Chinese with Type 2 diabetes.
Objectives This study aimed to explore associations between plasma free amino acids (PFAA) and risk of cardiovascular disease (CVD) in Chinese with Type 2 diabetes (T2D). Methods We retrieved 741 inpatients with T2D consecutively from tertiary hospital. Twenty-three PFAA were measured. CVD was defined as having coronary heart disease (CHD) or stroke. Principal component analysis was used to extract factors of PFAA. Factors and their components were introduced into binary logistic regressions as continuous and tertiles to obtain OR (odds ratio) and 95% confidence interval (CI) for CVD (or its components) risk. Results Of 741 inpatients, 282 (38.1%) had CVD (CHD alone: 122, stroke alone: 109, both: 51). Five factors were extracted, accounting for 65% of the total variance. Factor 3 composed of glutamate and tryptophan was associated with increased CVD risk (ORs, 95%CI of top vs. bottom tertiles: 1.60, 1.02-2.50 for CVD; 2.19, 1.17-4.07 for stroke, 1.51, 0.83-2.73 for CHD); the ORs (top vs. bottom tertiles) of glutamate were 2.62 (95%CI, 1.18-5.84) for stroke and 1.44 (0.80-2.61) for CHD; the ORs (top vs. bottom tertiles) of tryptophan were 1.50 (0.81-2.75) for stroke and 1.07 (0.58-1.97) for CHD. Comparable results were observed according to important confounders (all P for interaction >0.05). Conclusions Elevated factor 3 composed of glutamate and tryptophan was associated with increased CVD, especially stroke in T2D in China.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available