Journal
FRONTIERS IN ENDOCRINOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2021.646233
Keywords
diabetes mellitus; complication; microvascular damage; mesenchymal stem cells; exosomes
Categories
Funding
- east hospital affiliated to Tongji University introduced talent research startup fund [DFRC2019008]
- China Postdoctoral Science Foundation [2019M651587]
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Diabetes mellitus is a metabolic disease characterized by high blood sugar levels, often accompanied by various complications. Mesenchymal stem cell exosomes possess repair functions, low immunogenicity, and ease of storage and transportation, making them a potentially effective treatment for diabetes and its complications.
Diabetes mellitus (DM) is a metabolic disease, now prevalent worldwide, which is characterized by a relative or absolute lack of insulin secretion leading to chronically increased blood glucose levels. Diabetic patients are often accompanied by multiple macrovascular complications, such as coronary heart disease, hypertension, macrovascular arteriosclerosis, and microvascular complications. Microvascular complications include diabetic kidney injury, diabetic encephalopathy, and diabetic foot, which reduce the quality of life and survival status of patients. Mesenchymal stem cell exosomes (MSC-Exos) possess repair functions similar to MSCs, low immunogenicity, and ease of storage and transport. MSC-Exos have been proven to possess excellent repair effects in repairing various organ damages. This study reviews the application of MSC-Exos in the treatment of DM and its common complications. MSC-Exos may be used as an effective treatment for DM and its complications.
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