Evolution of the Insulin Gene: Changes in Gene Number, Sequence, and Processing

Insulin has not only made major contributions to the field of clinical medicine but has also played central roles in the advancement of fundamental molecular biology, including evolution. Insulin is essential for the health of vertebrate species, yet its function has been modified in species-specific manners. With the advent of genome sequencing, large numbers of insulin coding sequences have been identified in genomes of diverse vertebrates and have revealed unexpected changes in the numbers of genes within genomes and in their sequence that likely impact biological function. The presence of multiple insulin genes within a genome potentially allows specialization of an insulin gene. Discovery of changes in proteolytic processing suggests that the typical two-chain hormone structure is not necessary for all of inulin's biological activities.

Automated summary

Insulin has made significant contributions to clinical medicine and molecular biology, with genome sequencing revealing unexpected changes in insulin coding sequences in diverse vertebrates. The presence of multiple insulin genes potentially allows for specialized function, while changes in proteolytic processing suggest that the typical hormone structure may not be essential for all biological activities.