Journal
FRONTIERS IN GENETICS
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2021.510350
Keywords
coronary artery lesion; rs1751034; multi-drug resistance protein 4; intravenous immunoglobulin resistance; Kawasaki disease
Categories
Funding
- Guangdong Medical Research Foundation [A2018018]
- Natural Science Foundation of Guangdong Province [2016A030313836]
- Guangzhou Health and Family Planning Science and Technology Project [20191A011032, 20191A011025]
- Guangzhou Institute of Pediatrics/Guangzhou Women and Children's Medical Center [YIP-2018-027, IP-2019-018, IP-2019-020]
Ask authors/readers for more resources
The study revealed a significant association between the rs1751034 polymorphism of the MRP4 gene and IVIG resistance in Kawasaki disease, with an increased risk in patients with the CC genotype. Additionally, the presence of three or more risk genotypes was significantly linked to IVIG resistance in children younger than 5 years of age and males.
Background: Kawasaki disease (KD) is a systemic vasculitis in childhood, which mainly causes damage to coronary arteries, and intravenous immunoglobulin (IVIG) is the initial therapy. IVIG resistance increased risk of coronary complication in KD. And genetic background is involved in the occurrence of IVIG resistance. Our previous study indicated the susceptibility of Multi-drug resistance protein 4 (MRP4) SNPs to KD. This study was to clarify the relationship between MRP4 polymorphisms and IVIG resistance. Methods: We genotyped the six polymorphisms of MRP4 gene in 760 cases of KD using Taqman methods. Results: Among the six polymorphisms, only the rs1751034 polymorphism was significantly associated with IVIG resistance in KD [CC vs. TT: adjusted odds ratio (OR) = 2.54, 95% confidence interval (CI) = 1.21-5.34; CC vs. TT/TC: adjusted OR = 2.33, 95% CI = 1.12-4.83, p = 0.023]. Combined analysis of three polymorphisms indicated that patients with 3-6 risk genotypes exhibited significantly elevated risk of IVIG resistance, when compared with those with 0-2 risk genotypes (adjusted OR = 1.52, 95% CI = 1.04-2.22, p = 0.0295). Stratified analysis revealed that in term of age and gender, rs1751034 CC carriers were associated with increased risk of IVIG resistance in those aged <= 60 months (adjusted OR = 2.65, 95% CI = 1.23-5.71, p = 0.0133). The presence of three or more risk genotypes was significantly associated with risk of IVIG resistance in children younger than 5 years of age and males. Conclusion: Our results suggest that MRP4 rs1751034 CC is associated with increased risk of IVIG resistance in KD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available