Journal
FRONTIERS IN GENETICS
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2021.632164
Keywords
hsa_circ_0004543; atherosclerosis; angiogenesis; vascular endothelial cells; treatment
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Funding
- Department of Cardiology, Minhang Hospital
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The study revealed the significant role of hsa_circ_0004543 in atherosclerosis, showing its impact on the proliferation, migration, invasion, apoptotic rate, and PI3K/AKT/NOS3 pathway in HUVECs induced by oxLDL. This circRNA may serve as a potential target for treating endothelial cell damage in atherosclerosis.
Circular RNAs (circRNAs) are novel non-coding RNAs, which show abnormal expression in several diseases, such as atherosclerosis (AS). The purpose of the present study was to reveal the association between hsa_circ_0004543 and AS. In the present study, hsa_circ_0004543 was overexpressed in human umbilical vein endothelial cells (HUVECs) induced by oxidized low-density lipoprotein (oxLDL). Inhibition of hsa_circ_0004543 expression facilitated the proliferation, migration, and invasion of HUVECs and significantly reduced their apoptotic rate following treatment with oxLDL. Furthermore, silencing of hsa_circ_0004543 activated the PI3K/AKT/NOS3 pathway in oxLDL-induced HUVECs. Collectively, these results demonstrated that hsa_circ_0004543 may play a vital role in the development of AS and affect the proliferation of HUVECs, providing a potential target for treating endothelial cell damage in AS.
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