Journal
FRONTIERS IN GENETICS
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2021.638730
Keywords
hereditary spastic paraplegia; hereditary cerebellar ataxia; spinocerebellar ataxia; spinocerebellar degeneration; gene discovery; diagnosis; neurogenetics
Categories
Funding
- European Union [779257]
- Spastic Paraplegia Foundation (US)
- HSP-ASL-France
- association Connaitre les Syndromes Cerebelleux
- Ministry of Higher Education in Sudan
- French embassy in Sudan
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Hereditary spinocerebellar degeneration (SCD) comprises a group of rare diseases with diverse clinical and genetic characteristics, making diagnosis and management challenging. Precision medicine relies on accurate diagnosis, and discovering genes causing unknown conditions can guide patient and family management and lead to the identification of more genetic diseases.
Hereditary spinocerebellar degeneration (SCD) encompasses an expanding list of rare diseases with a broad clinical and genetic heterogeneity, complicating their diagnosis and management in daily clinical practice. Correct diagnosis is a pillar for precision medicine, a branch of medicine that promises to flourish with the progressive improvements in studying the human genome. Discovering the genes causing novel Mendelian phenotypes contributes to precision medicine by diagnosing subsets of patients with previously undiagnosed conditions, guiding the management of these patients and their families, and enabling the discovery of more causes of Mendelian diseases. This new knowledge provides insight into the biological processes involved in health and disease, including the more common complex disorders. This review discusses the evolution of the clinical and genetic approaches used to diagnose hereditary SCD and the potential of new tools for future discoveries.
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