Journal
FRONTIERS IN CHEMISTRY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2021.619052
Keywords
boron cluster; oligonucleotide conjugate; conjugation method; pre; and post-synthetic modification; BNCT; boron neutron capture therapy
Categories
Funding
- Russian Scientific Foundation [19-74-20127]
- Russian Science Foundation [19-74-20127] Funding Source: Russian Science Foundation
Ask authors/readers for more resources
Boron clusters show promise as therapeutic tools for BNCT due to their high boron content, stability, and low toxicity. By developing oligonucleotide constructs with boron clusters, high boron-loaded agents can be created that interact specifically with nucleic acids in cells, offering new possibilities for BNCT treatments.
Boron clusters attract considerable attention as promising therapeutic tools for boron neutron capture therapy (BNCT). They combine high boron content with high chemical and biological stability, biorthogonality, and low toxicity. The development of oligonucleotide-based constructs and nucleic acid-like molecules, such as oligomeric phosphate diesters, bearing one or multiple boron clusters permits to create potential high boron-loaded agents for BNCT with good bioavailability, specifically interacting with nucleic acids inside the cell. Here, we shortly review the strategies and solutions in the design of oligonucleotide conjugates with boron clusters in light of the requirements for effective BNCT and future prospects of their practical use.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available