Journal
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 51, Issue 3, Pages 499-513Publisher
UNIV SAO PAULO, CONJUNTO QUIMICAS
DOI: 10.1590/S1984-82502015000300002
Keywords
Nutraceuticals; Natural polyphenols; Resveratrol/mechanisms of action; Resveratrol/therapeutic applications; Resveratrol/delivery systems
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Resveratrol (RSV), a natural polyphenol found in grapes, was found to be effective in the prevention and therapy of several diseases, however, it does have unfavourable physicochemical properties. In this context, an increasing number of studies have aimed at developing novel therapeutic systems for its delivery to overcome these disadvantages. This review focuses on the mechanisms of action and therapeutic applications. Finally, it also describes some tested formulations for RSV administration, controlled release and targeting, developed with the purpose of increasing RSV bioavailability.
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