Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines

The novel coronavirus SARS-CoV-2, the cause of the COVID-19 pandemic, has inspired one of the most efficient vaccine development campaigns in human history. A key aspect of COVID-19 mRNA vaccines is the use of the modified nucleobase N1-methylpseudouridine (m1 Psi) to increase their effectiveness. In this Outlook, we summarize the development and function of m1 Psi in synthetic mRNAs. By demystifying how a novel element within these medicines works, we aim to foster understanding and highlight future opportunities for chemical innovation.

Automated summary

The COVID-19 mRNA vaccines have utilized the modified nucleobase N1-methylpseudouridine (m1 Psi) to enhance effectiveness, contributing to one of the most efficient vaccine development campaigns. By explaining the development and function of m1 Psi in synthetic mRNAs, this article aims to promote understanding and highlight potential opportunities for chemical innovation in the future.