4.7 Review

A tale of two rhythms: Locked clocks and chaos in biology

Journal

CELL SYSTEMS
Volume 12, Issue 4, Pages 291-303

Publisher

CELL PRESS
DOI: 10.1016/j.cels.2021.03.003

Keywords

-

Funding

  1. Danish Council for Independent Research
  2. Danish National Research Foundation through StemPhys Center of Excellence [DNRF116]
  3. Simons Foundation
  4. Q-life [ANR-17CONV-0005]

Ask authors/readers for more resources

The fundamental mechanisms controlling biological organisms exhibit complex dynamics, with oscillators being a common motif that interacts with each other. Understanding the non-linear interactions between oscillations is crucial for predicting the dynamic effects in biological systems.
The fundamental mechanisms that control and regulate biological organisms exhibit a surprising level of complexity. Oscillators are perhaps the simplest motifs that produce time-varying dynamics and are ubiquitous in biological systems. It is also known that such biological oscillators interact with each other-for instance, circadian oscillators affect the cell cycle, and somitogenesis clock proteins in adjacent cells affect each other in developing embryos. Therefore, it is vital to understand the effects that can emerge from non-linear interaction between oscillations. Here, we show how oscillations typically arise in biology and take the reader on a tour through the great variety in dynamics that can emerge even from a single pair of coupled oscillators. We explain how chaotic dynamics can emerge and outline the methods of detecting this in experimental time traces. Finally, we discuss the potential role of such complex dynamical features in biological systems.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available