Journal
NATIONAL SCIENCE REVIEW
Volume 8, Issue 6, Pages -Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nsr/nwab068
Keywords
aggregation-induced emission (AIE); cationic liposomes; protein corona; endocytosis; membrane fusion
Categories
Funding
- National Natural Science Foundation of China (NSFC) Key Projects [31630027, 32030060]
- Fundamental Research Funds for the Central Universities [C029201016]
- NSFC International Collaboration Key Project [51861135103]
- NSFC-German Research Foundation (DFG) Project [31761133013]
- Beijing-Tianjin-Hebei Basic Research Cooperation Project [19JCZDJC64100]
- Ten Thousand Elite Plan [Y9E21Z11]
- Chinese Academy of Sciences International Collaboration Plan [E0632911ZX]
- National Key Research andDevelopment Program of China [2018YFE0117800]
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The protein corona can alter the cellular transportation mechanism of liposomes and modulate the intracellular distribution of loaded cargoes. This finding contributes to a better understanding of bio-nano interactions and is crucial for the efficient utilization of cationic liposomes.
Liposomes, especially cationic liposomes, are the most common and well-investigated nanocarriers for biomedical applications, such as drug and gene delivery. Like other types of nanomaterials, once liposomes are incubated in a biological milieu, their surface can be immediately cloaked by biological components to form a protein corona, which confers a new `biological identity' and modulates downstream interactions with cells. However, it remains unclear how the protein corona affects the transportation mechanism after liposomes interact with cells. Here, we employed home-made aggregation-induced-emission-visualized nanoliposomes TR4@Lipo as a model to investigate transportation with or without the protein corona by optical imaging techniques. The results show that the protein corona can change the cellular transportation mechanism of TR4@Lipo from energy-independent membrane fusion to energy-dependent endocytosis. The protein corona also modulates the intracellular distribution of loaded cargoes. This knowledge furthers our understanding of bio-nano interactions and is important for the efficient use of cationic liposomes.
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