Endothelial dysfunction in COVID-19 calls for immediate attention: the emerging roles of the endothelium in inflammation caused by SARS-CoV-2

The COVID-19 pandemic has caused numerous deaths around the world. A growing body of evidence points to the important role of overwhelming inflammatory responses in the pathogenesis of COVID-19 and the effectiveness of anti-inflammation therapy against COVID-19 is emerging. In addition to affecting the lungs, COVID-19 can be a severe systemic inflammatory disease that is related to endothelial dysfunction. We are calling for closer attention to endothelial dysfunction in COVID-19 not only for fully revealing the pathogenic mechanism of COVID-19 but also for properly adjusting the strategy of clinical intervention.

Automated summary

The COVID-19 pandemic has resulted in a large number of deaths globally, with endothelial dysfunction playing a key role in the pathogenesis and anti-inflammation therapy showing effectiveness. There is a call for more attention to be paid to endothelial dysfunction in order to reveal the pathogenic mechanism of COVID-19 and adjust clinical intervention strategies appropriately.