Journal
FRONTIERS IN IMMUNOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.636896
Keywords
community-acquired pneumonia; IL-37; inflammatory cytokine; community-acquired pneumonia severity score; biomarker
Categories
Funding
- National Natural Science Foundation Incubation Program of the Second Affiliated Hospital of Anhui Medical University [2020GQFY05]
- Scientific Research of Health Commission in Anhui Province [AHWJ2021b091]
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The study revealed a significant negative correlation between serum IL-37 levels and the severity and prognosis of CAP patients. Lower levels of serum IL-37 upon admission were associated with prolonged hospital stay, indicating a potential role of IL-37 in the development of CAP. Serum IL-37 may serve as a biomarker for diagnosis and prognosis in CAP patients.
Background Recent evidences suggested that IL-37 may participate in the pathophysiology of community-acquired pneumonia (CAP). Nevertheless, its exact biological role was unknown. The objective of this study was to determine the associations of serum IL-37 with the severity and prognosis in CAP patients based on a retrospective cohort study. Methods The whole of 120 healthy subjects and 240 CAP patients were summoned. Peripheral blood was collected and IL-37 was detected using ELISA. Results Serum IL-37 was obviously decreased in CAP patients on admission. In addition, serum IL-37 was gradually decreased in parallel with CAP severity scores. Correlative analysis revealed that serum IL-37 was negatively associated with CAP severity scores and inflammatory cytokines. Further logistical regression found that reduction of serum IL-37 augmented the severity of CAP patients. Moreover, the follow-up research was performed in CAP patients. Serum lower IL-37 on admission prolonged the hospital stay in CAP patients. Serum IL-37 combination with PSI and CURB-65 had a stronger predictive capacity for death than IL-37 and CAP severity score alone in CAP patients. Conclusion There are remarkably negative correlations between serum IL-37 with the severity and prognosis in CAP patients. Serum IL-37 on admission prolongs the hospital stay, demonstrating that IL-37 may involve in the process of CAP. Serum IL-37 may be regarded as a biomarker for diagnosis and prognosis for CAP patients.
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