Journal
FRONTIERS IN IMMUNOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.671479
Keywords
immunosenescence and inflammaging; immunosenescence; immune aging; senescent cell; passenger leukocytes; senescent associated secretory phenotype
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Funding
- NIA NIH HHS [R01 AG064165] Funding Source: Medline
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The transplantation of aged organs may have negative effects on recipients due to the accumulation of senescent cells, which can promote aging in recipient cells through the secretion of pro-inflammatory molecules. Studies have shown that transplanting old organs may limit the physical reserve of recipients.
In transplantation, donor and recipients frequently differ in age. Senescent cells accumulate in donor organs with aging and have the potential to promote senescence in adjacent cells when transferred into recipient animals. Characteristically, senescent cells secrete a myriad of pro-inflammatory, soluble molecules as part of their distinct secretory phenotype that have been shown to drive senescence and age-related co-morbidities. Preliminary own data show that the transplantation of old organs limits the physical reserve of recipient animals. Here, we review how organ age may affect transplant recipients and discuss the potential of accelerated aging.
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