Journal
FRONTIERS IN IMMUNOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.658535
Keywords
bone marrow; hematopoietic stem and progenitor cell niches; multipotent progenitors; plasma cells; lymphoid lineage; CXCR4; WHIM syndrome
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Funding
- ANR [ANR-19-CE15-0019-01, ANR-17-CE14-0019]
- Fondation ARC pour la recherche sur le cancer grant
- INCa grant [PRT-K 2017]
- Association Saint Louis pour la Recherche sur les Leucemies
- IdEx Universite de Paris [ANR-18-IDEX-0001]
- PRESTIGE program [PCOFUND-GA-2013609102]
- European Union's Seventh Framework Program (FP7/2007-2013) under REA grant agreement
- Agence Nationale de la Recherche (ANR) [ANR-19-CE15-0019] Funding Source: Agence Nationale de la Recherche (ANR)
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This review explores the bone marrow niches in mice that support hematopoietic cells, focusing on the roles of multipotent progenitors and plasma cells. The chemokine CXCL12/CXCR4 signaling axis is highlighted for its importance in these processes. The question of whether multipotent progenitors and plasma cells are neighbors or roommates within the bone marrow is raised for further exploration.
The bone marrow is a complex ecosystem in which hematopoietic and non-hematopoietic cells reside. In this review, we discuss the bone marrow niches in mice that facilitate the survival, maintenance, and differentiation of cells of hematopoietic origin based on the recent literature. Our review places a special focus on the hematopoietic multipotent progenitors and on plasma cells, corresponding to the last stage of the B-cell lineage, that play a key role in the humoral memory response. We highlight the similarities between the microenvironments necessary for the establishment and the maintenance of these two immune cell subsets, and how the chemokine CXCL12/CXCR4 signaling axis contributes to these processes. Finally, we bring elements to address the following question: are multipotent progenitors and plasma cells neighbors or roommates within the bone marrow?
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