Journal
FRONTIERS IN IMMUNOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.585316
Keywords
immune reconstitution inflammatory syndrome; bacterial meningitis; Staphylococcus aureus; pregnancy; case report
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Funding
- National Natural Science Foundation of China [81971110, 81671178]
- Guangdong Basic and Applied Basic Research Foundation [2020A1515010056]
- Third Affiliated Hospital of SunYat-SenUniversity, ClinicalResearch Program [QHJH201907]
- Doctorial Starting Fund of GuangzhouWomen and Children's Medical Center [2018-293]
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CNS-IRIS is an inflammatory syndrome that may occur in previously immunocompromised patients during the restoration of immunity function. This case report presents the first instance of CNS-IRIS associated with bacterial meningitis, where the patient gradually recovered with corticosteroid therapy.
Central nervous system immune reconstitution inflammatory syndrome (CNS-IRIS) describes clinical characteristics that may be observed in previously immunocompromised patients during rapid restoration of immunity function in the presence of a pathogen. There have been no reports about CNS-IRIS related to bacterial meningitis so far. Here, we report a 24-year-old pregnant female patient with bacterial meningitis. Her clinical and neuroradiological condition worsened after induced labor despite great effective anti-infective therapy. CNS-IRIS was considered. Corticosteroids were administered, and the patient gradually recovered. We present the first case of CNS-IRIS associated with bacterial meningitis.
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