4.8 Review

The IL23-IL17 Immune Axis in the Treatment of Ulcerative Colitis: Successes, Defeats, and Ongoing Challenges

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

Results of the Seventh Scientific Workshop of ECCO: Precision Medicine in IBD-Disease Outcome and Response to Therapy

Bram Verstockt et al.

Summary: The ECCO workshop aims to provide a state-of-the-art overview on prognostic and predictive markers in IBD, shed light on key questions in biomarker development, and discuss the potential for multi-omic data integration to make precision medicine a reality in IBD.

JOURNAL OF CROHNS & COLITIS (2021)

Article Gastroenterology & Hepatology

Real-World Effectiveness and Safety of Ustekinumab for Ulcerative Colitis From 2 Tertiary IBD Centers in the United States

Simon J. Hong et al.

Summary: In this retrospective study conducted at two US tertiary inflammatory bowel disease centers, ustekinumab treatment achieved remission in nearly half of UC patients at 12 months and was associated with an overall favorable safety profile. These results are modestly better than the pivotal trials, confirming ustekinumab as an effective and safe option for patients with moderate to severely active ulcerative colitis.

CROHNS & COLITIS 360 (2021)

Article Gastroenterology & Hepatology

Real-World Effectiveness and Safety of Ustekinumab for Ulcerative Colitis From 2 Tertiary IBD Centers in the United States

Simon J. Hong et al.

Summary: This retrospective study analyzed the effectiveness and safety of ustekinumab in patients with moderately to severely active ulcerative colitis at two US tertiary inflammatory bowel disease centers. The results showed that nearly half of the patients achieved remission at 12 months, with an overall favorable safety profile.

CROHNS & COLITIS 360 (2021)

Review Gastroenterology & Hepatology

Leukocytoclastic Vasculitis Related to Ustekinumab in a Crohn's Disease Patient: First Case Report and Literature Review

Pedro Costa-Moreira et al.

JOURNAL OF CROHNS & COLITIS (2020)

Article Gastroenterology & Hepatology

Efficacy and Safety of Mirikizumab in a Randomized Phase 2 Study of Patients With Ulcerative Colitis

William J. Sandborn et al.

GASTROENTEROLOGY (2020)

Article Gastroenterology & Hepatology

DOP65 Mirikizumab regulates genes involved in anti-TNF resistance and ulcerative colitis disease activity

B Steere et al.

Journal of Crohns & Colitis (2020)

Article Gastroenterology & Hepatology

P687 Early and sustained improvement in stool frequency and rectal bleeding following 52 weeks of mirikizumab treatment

G R D’Haens et al.

Journal of Crohns & Colitis (2020)

Article Gastroenterology & Hepatology

P434 Effectiveness and safety of ustekinumab in ulcerative colitis: real-world evidence from Eneida Registry

M Chaparro et al.

Journal of Crohns & Colitis (2020)

Article Gastroenterology & Hepatology

S2261 Combining Cyclosporine With Ustekinumab in Acute Severe Ulcerative Colitis: Report of 2 Cases

Seth R. Shaffer et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2020)

Article Gastroenterology & Hepatology

S0683 Absence of Bowel Urgency Is Associated With Improvements in Clinical Outcomes in Patients With Ulcerative Colitis Receiving Mirikizumab

Marla C. Dubinsky et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2020)

Article Gastroenterology & Hepatology

S0845 Pharmacokinetics and Immunogenicity of Maintenance Therapy With Ustekinumab: 2-Year Results From the UNIFI Long-Term Extension Study

Omoniyi Adedokun et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2020)

Article Gastroenterology & Hepatology

Gut microbiome composition and risk factors in a large cross-sectional IBS cohort

Melissa Agnello et al.

BMJ OPEN GASTROENTEROLOGY (2020)

Article Dermatology

Incidence and Risk of Inflammatory Bowel Disease in Patients with Psoriasis-A Nationwide 20-Year Cohort Study

Alexander Egeberg et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2019)

Article Medicine, General & Internal

Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis

B. E. Sands et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Biochemistry & Molecular Biology

IL-23 in inflammatory bowel diseases and colon cancer

Markus F. Neurath

CYTOKINE & GROWTH FACTOR REVIEWS (2019)

Review Gastroenterology & Hepatology

IL-12, IL-23 and IL-17 in IBD: immunobiology and therapeutic targeting

Alexander R. Moschen et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

Article Gastroenterology & Hepatology

Can IL-23 be a good target for ulcerative colitis?

Mariangela Allocca et al.

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY (2018)

Article Gastroenterology & Hepatology

Evaluation of interleukin 23 (IL-23) as a non-invasive test of disease severity in patients with ulcerative colitis

Tarek Youssef et al.

ARAB JOURNAL OF GASTROENTEROLOGY (2018)

Article Gastroenterology & Hepatology

Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 2: Current Management

Marcus Harbord et al.

JOURNAL OF CROHNS & COLITIS (2017)

Article Biochemistry & Molecular Biology

Meta-Analysis of Risk Association Between Interleukin-17A and F Gene Polymorphisms and Inflammatory Diseases

Ebrahim Eskandari-Nasab et al.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2017)

Review Medicine, General & Internal

Ulcerative colitis

Ryan Ungaro et al.

LANCET (2017)

Article Medicine, General & Internal

Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis

William J. Sandborn et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Gastroenterology & Hepatology

IL23R single nucleotide polymorphisms could be either beneficial or harmful in ulcerative colitis

Sarah Fischer et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2017)

Article Immunology

mTOR Mediates IL-23 Induction of Neutrophil IL-17 and IL-22 Production

Feidi Chen et al.

JOURNAL OF IMMUNOLOGY (2016)

Review Biochemistry & Molecular Biology

IL-17 in Chronic Inflammation: From Discovery to Targeting

Audrey Beringer et al.

TRENDS IN MOLECULAR MEDICINE (2016)

Review Rheumatology

The IL-23-IL-17 axis in inflammatory arthritis

Erik Lubberts

NATURE REVIEWS RHEUMATOLOGY (2015)

Review Medicine, General & Internal

Biological Agents for Moderately to Severely Active Ulcerative Colitis A Systematic Review and Network Meta-analysis

Silvio Danese et al.

ANNALS OF INTERNAL MEDICINE (2014)

Review Biochemistry & Molecular Biology

Role of the Microbiota in Immunity and Inflammation

Yasmine Belkaid et al.

Article Gastroenterology & Hepatology

Interleukin-17 SNPs and serum levels increase ulcerative colitis risk: A meta-analysis

Juan Li et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

Review Immunology

The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing

Sarah L. Gaffen et al.

NATURE REVIEWS IMMUNOLOGY (2014)

Article Medicine, Research & Experimental

Influence of IL17A polymorphisms (rs2275913 and rs3748067) on the susceptibility to ulcerative colitis

Ranji Hayashi et al.

CLINICAL AND EXPERIMENTAL MEDICINE (2013)

Article Biochemistry & Molecular Biology

IL-23/IL-17A Axis Correlates with the Nitric Oxide Pathway in Inflammatory Bowel Disease: Immunomodulatory Effect of Retinoic Acid

Hayet Rafa et al.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2013)

Article Medicine, General & Internal

Vedolizumab as Induction and Maintenance Therapy for Ulcerative Colitis

Brian G. Feagan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Medicine, General & Internal

Vedolizumab as Induction and Maintenance Therapy for Crohn's Disease

William J. Sandborn et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Review Gastroenterology & Hepatology

Ulcerative colitis as a progressive disease: The forgotten evidence

Joana Torres et al.

INFLAMMATORY BOWEL DISEASES (2012)

Review Gastroenterology & Hepatology

Review of the disease course among adult ulcerative colitis population-based longitudinal cohorts

Fernando Magro et al.

INFLAMMATORY BOWEL DISEASES (2012)

Article Immunology

Cutting Edge: Regulation of Intestinal Inflammation and Barrier Function by IL-17C

Joseph M. Reynolds et al.

JOURNAL OF IMMUNOLOGY (2012)

Article Biochemistry & Molecular Biology

Toll-Like Receptor 5 Engagement Induces Interleukin-17C Expression in Intestinal Epithelial Cells

Eunok Im et al.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2012)

Article Gastroenterology & Hepatology

Epidemiology and Natural History of Inflammatory Bowel Diseases

Jacques Cosnes et al.

GASTROENTEROLOGY (2011)

Article Immunology

The increased mucosal mRNA expressions of complement C3 and interleukin-17 in inflammatory bowel disease

T. Sugihara et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2010)

Article Biochemistry & Molecular Biology

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

Ivaylo I. Ivanov et al.

Article Immunology

A protective function for interleukin 17A in T cell-mediated intestinal inflammation

William O'Connor et al.

NATURE IMMUNOLOGY (2009)

Review Immunology

The gut microbiota shapes intestinal immune responses during health and disease

June L. Round et al.

NATURE REVIEWS IMMUNOLOGY (2009)

Article Immunology

Regulation of inflammatory responses by IL-17F

Xuexian O. Yang et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2008)

Article Immunology

Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells

Franca Gerosa et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2008)

Review Immunology

IL-23 and Th17 cytokines in intestinal homeostasis

K. J. Maloy et al.

MUCOSAL IMMUNOLOGY (2008)

Review Immunology

The IL-23/Th17axis:: therapeutic targets for autoimmune inflammation

Kristine Kikly et al.

CURRENT OPINION IN IMMUNOLOGY (2006)

Article Multidisciplinary Sciences

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

Richard H. Duerr et al.

SCIENCE (2006)

Article Immunology

IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis

Marika C. Kullberg et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2006)

Article Multidisciplinary Sciences

Symbiotic bacteria direct expression of an intestinal bactericidal lectin

Heather L. Cash et al.

SCIENCE (2006)

Article Gastroenterology & Hepatology

Critical role of IL-17 receptor signaling in acute TNBS-induced colitis

Z Zhang et al.

INFLAMMATORY BOWEL DISEASES (2006)

Article Medicine, Research & Experimental

IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6

D Yen et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

Article Gastroenterology & Hepatology

Increased expression of interleukin 17 in inflammatory bowel disease

S Fujino et al.

Article Gastroenterology & Hepatology

Claudins regulate the intestinal barrier in response to immune mediators

T Kinugasa et al.

GASTROENTEROLOGY (2000)

Article Multidisciplinary Sciences

Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family

HZ Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)