4.8 Article

Neurological Symptoms of COVID-19: The Zonulin Hypothesis

Related references

Note: Only part of the references are listed.
Article Immunology

Direct Evidence of Active SARS-CoV-2 Replication in the Intestine

Qun Qian et al.

Summary: The study investigated the presence of SARS-CoV-2 virions and pathological changes in the rectal tissues of a COVID-19 patient with rectal adenocarcinoma. Results showed evidence of active replication of SARS-CoV-2 in the patient's rectum during the incubation period, potentially explaining fecal-oral transmission of the virus.

CLINICAL INFECTIOUS DISEASES (2021)

Review Biochemistry & Molecular Biology

Immune response and blood-brain barrier dysfunction during viral neuroinvasion

Zhuangzhuang Chen et al.

Summary: The blood-brain barrier (BBB) is crucial for maintaining brain homeostasis, composed of specialized brain microvascular endothelial cells joined by tight junctions. Infection with neurotropic viruses may disrupt BBB structure and function, activating immune responses. Exploring the interaction between host and pathogen at the BBB helps propose new treatments for viral encephalitis.

INNATE IMMUNITY (2021)

Article Multidisciplinary Sciences

SARS-CoV-2 induced intestinal responses with a biomimetic human gut-on-chip

Yaqiong Guo et al.

Summary: The research team developed an intestinal infection model on a chip that recapitulates the pathophysiology induced by SARS-CoV-2 at the organ level, providing insights into the intestinal barrier injury caused by viral infection. The model reconstructs key features of the intestinal epithelium-vascular endothelium barrier through 3D co-culture, offering a unique and rapid platform for COVID-19 research.

SCIENCE BULLETIN (2021)

Article Chemistry, Multidisciplinary

In silico Analysis Revealed Potential Anti-SARS-CoV-2 Main Protease Activity by the Zonulin Inhibitor Larazotide Acetate

Simone Di Micco et al.

Summary: The study identified a potential drug called AT1001, which could potentially improve both acute lung injury/acute respiratory distress syndrome and combat against SARS-CoV-2, providing an important treatment option for tackling the current pandemic.

FRONTIERS IN CHEMISTRY (2021)

Review Clinical Neurology

SARS-CoV-2 Infection: Symptoms of the Nervous System and Implications for Therapy in Neurological Disorders

Jacek Losy

Summary: This paper presents the neurological aspects of COVID-19, emphasizing the importance of understanding the virus's impact on the nervous system for physicians in diagnosis and prevention. COVID-19 infection may lead to symptoms of both the central nervous system and the peripheral nervous system, requiring prompt diagnosis and treatment.

NEUROLOGY AND THERAPY (2021)

Editorial Material Gastroenterology & Hepatology

Evidence for Gastrointestinal Infection of SARS-CoV-2

Fei Xiao et al.

GASTROENTEROLOGY (2020)

Letter Gastroenterology & Hepatology

SARS-CoV-2 induced diarrhoea as onset symptom in patient with COVID-19

Y. Song et al.

Article Medicine, General & Internal

First Case of 2019 Novel Coronavirus in the United States

Michelle L. Holshue et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

A Novel Coronavirus from Patients with Pneumonia in China, 2019

Na Zhu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Letter Immunology

Can the enteric nervous system be an alternative entrance door in SARS-CoV2 neuroinvasion?

Giuseppe Esposito et al.

BRAIN BEHAVIOR AND IMMUNITY (2020)

Review Gastroenterology & Hepatology

Clinical Insights into the Gastrointestinal Manifestations of COVID-19

Jonathan Kopel et al.

DIGESTIVE DISEASES AND SCIENCES (2020)

Article Medicine, Research & Experimental

The role of interleukin-6 in monitoring severe case of coronavirus disease 2019

Tao Liu et al.

EMBO MOLECULAR MEDICINE (2020)

Article Multidisciplinary Sciences

SARS-CoV-2 productively infects human gut enterocytes

Mart M. Lamers et al.

SCIENCE (2020)

Editorial Material Virology

Central nervous system involvement by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)

Alberto Paniz-Mondolfi et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

Review Urology & Nephrology

The case of complement activation in COVID-19 multiorgan impact

Marina Noris et al.

KIDNEY INTERNATIONAL (2020)

Letter Medicine, General & Internal

COVID-19: consider cytokine storm syndromes and immunosuppression

Puja Mehta et al.

LANCET (2020)

Article Multidisciplinary Sciences

Virological assessment of hospitalized patients with COVID-2019

Roman Woelfel et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

Infection of bat and human intestinal organoids by SARS-CoV-2

Zhou Jie et al.

NATURE MEDICINE (2020)

Editorial Material Gastroenterology & Hepatology

COVID-19: faecal-oral transmission?

Jordan Hindson

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

Article Clinical Neurology

Neurologic manifestations in hospitalized patients with COVID-19 The ALBACOVID registry

Carlos Manuel Romero-Sanchez et al.

NEUROLOGY (2020)

Letter Gastroenterology & Hepatology

Prolonged presence of SARS-CoV-2 viral RNA in faecal samples

Yongjian Wu et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2020)

Review Gastroenterology & Hepatology

The mechanism and treatment of gastrointestinal symptoms in patients with COVID-19

Qing Ye et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2020)

Review Biochemistry & Molecular Biology

SARS-CoV-2 and the Nervous System: From Clinical Features to Molecular Mechanisms

Manuela Pennisi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Medicine, General & Internal

Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19) A Review

W. Joost Wiersinga et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Article Multidisciplinary Sciences

Identifying airborne transmission as the dominant route for the spread of COVID-19

Renyi Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Otorhinolaryngology

Association of chemosensory dysfunction and COVID-19 in patients presenting with influenza-like symptoms

Carol H. Yan et al.

INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY (2020)

Review Neurosciences

Possible routes of SARS-CoV-2 invasion in brain: In context of neurological symptoms in COVID-19 patients

Ashutosh Kumar et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2020)

Article Clinical Neurology

Lifting the mask on neurological manifestations of COVID-19

Alessandro Pezzini et al.

NATURE REVIEWS NEUROLOGY (2020)

Article Multidisciplinary Sciences

Interleukine-6 in critically ill COVID-19 patients: A retrospective analysis

Julie Gorham et al.

PLOS ONE (2020)

Article Multidisciplinary Sciences

Immune suppression in the early stage of COVID-19 disease

Wenmin Tian et al.

NATURE COMMUNICATIONS (2020)

Article Medicine, General & Internal

COVID-19 Patients Upregulate Toll-like Receptor 4-mediated Inflammatory Signaling That Mimics Bacterial Sepsis

Kyung Mok Sohn et al.

JOURNAL OF KOREAN MEDICAL SCIENCE (2020)

Letter Infectious Diseases

Stability of SARS-CoV-2 in different environmental conditions

Alex W. H. Chin et al.

LANCET MICROBE (2020)

Review Immunology

The Contribution of Gut Barrier Changes to Multiple Sclerosis Pathophysiology

Maria Chiara Buscarinu et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Physiology

BLOOD-BRAIN BARRIER: FROM PHYSIOLOGY TO DISEASE AND BACK

Melanie D. Sweeney et al.

PHYSIOLOGICAL REVIEWS (2019)

Review Infectious Diseases

TLR2 and TLR4 mediated host immune responses in major infectious diseases: a review

Suprabhat Mukherjee et al.

BRAZILIAN JOURNAL OF INFECTIOUS DISEASES (2016)

Article Mechanics

Violent expiratory events: on coughing and sneezing

Lydia Bourouiba et al.

JOURNAL OF FLUID MECHANICS (2014)

Review Biochemistry & Molecular Biology

Complement and blood-brain barrier integrity

Alexander Jacob et al.

MOLECULAR IMMUNOLOGY (2014)

Article Physiology

Zonulin as prehaptoglobin2 regulates lung permeability and activates the complement system

Daniel Rittirsch et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2013)

Article Multidisciplinary Sciences

Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2

Amit Tripathi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Oncology

Expression of Zonulin, c-kit, and Glial Fibrillary Acidic Protein in Human Gliomas

Marco Skardelly et al.

TRANSLATIONAL ONCOLOGY (2009)

Article Biochemistry & Molecular Biology

Analysis of proteinase-activated receptor 2 and TLR4 signal transduction - A novel paradigm for receptor cooperativity

Prasad Rallabhandi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Pharmacology & Pharmacy

Therapeutic promise of proteinase-activated receptor-2 antagonism in joint inflammation

EB Kelso et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)

Review Physiology

Tight junction biology and kidney dysfunction

DBN Lee et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2006)

Review Microbiology

Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus

SR Weiss et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2005)

Article Immunology

Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome

CK Wong et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2004)

Review Physiology

Protease-activated receptors: Contribution to physiology and disease

VS Ossovskaya et al.

PHYSIOLOGICAL REVIEWS (2004)

Review Immunology

Toll-like receptor signalling

S Akira et al.

NATURE REVIEWS IMMUNOLOGY (2004)