Frequency of Effector Memory Cells Expressing Integrin α4β7 Is Associated With TGF-β1 Levels in Therapy Naive HIV Infected Women With Low CD4+ T Cell Count

Integrin alpha(4)beta(7) expressing CD4(+) T cells are preferred targets for HIV infection and are thought to be predictors of disease progression. Concurrent analysis of integrin alpha(4)beta(7) expressing innate and adaptive immune cells was carried out in antiretroviral (ART) therapy naive HIV infected women in order to determine its contribution to HIV induced immune dysfunction. Our results demonstrate a HIV infection associated decrease in the frequency of integrin alpha(4)beta(7) expressing endocervical T cells along with an increase in the frequency of integrin alpha(4)beta(7) expressing peripheral monocytes and central memory CD4(+) T cells, which are considered to be viral reservoirs. We report for the first time an increase in levels of soluble MAdCAM-1 (sMAdCAM-1) in HIV infected individuals as well as an increased frequency and count of integrin beta 7Hi CD8(+) memory T cells. Correlation analysis indicates that the frequency of effector memory CD8(+) T cells expressing integrin alpha(4)beta(7) is associated with levels of both sMAdCAM-1 and TGF-beta 1. The results of this study also suggest HIV induced alterations in T cell homeostasis to be on account of disparate actions of sMAdCAM-1 and TGF-beta 1 on integrin alpha(4)beta(7) expressing T cells. The immune correlates identified in this study warrant further investigation to determine their utility in monitoring disease progression.

Automated summary

The study found that HIV infection can lead to a decrease in the frequency of certain T cells expressing Integrin alpha(4)beta(7), but an increase in the frequency of other types of cells, potentially contributing to HIV-induced immune dysfunction and viral reservoirs. Correlation analysis also suggests associations between effector memory CD8(+) T cells expressing Integrin alpha(4)beta(7) and levels of sMAdCAM-1 and TGF-beta 1.