Journal
FRONTIERS IN IMMUNOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.661678
Keywords
positive selection; cMyc; affinity maturation; permissive selection; clonal diversity
Categories
Funding
- Francis Crick Institute from Cancer Research UK [FC001057]
- UK Medical Research Council [FC001057, MR/J008060]
- Wellcome Trust [FC001057]
- MRC [MR/J008060/1] Funding Source: UKRI
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Germinal centers play a crucial role in the production of high-affinity antibody secreting plasma cells and memory-B cells for vaccination. The positive selection process in GCs guides B cell fates towards becoming either PCs, MBCs or persistent GC-B cells, with each cell type playing a specific role in the immune response.
Germinal centers (GCs) are essential sites for the production of high-affinity antibody secreting plasma cells (PCs) and memory-B cells (MBCs), which form the framework of vaccination. Affinity maturation and permissive selection in GCs are key for the production of PCs and MBCs, respectively. For these purposes, GCs positively select fit cells in the light zone of the GC and instructs them for one of three known B cell fates: PCs, MBCs and persistent GC-B cells as dark zone entrants. In this review, we provide an overview of the positive selection process and discuss its mechanisms and how B cell fates are instructed.
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