Journal
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
Volume 11, Issue 4, Pages 1323-1339Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s13346-021-00963-0
Keywords
Ultrasound-responsive; Polymeric materials; Drug delivery; Targeted therapy; Infectious diseases
Funding
- National Natural Science Foundation of China [21925505, 21674081]
- China Postdoctoral Science Foundation [2020M671197]
- 5-year national science fund for distinguished young scholars
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Ultrasound-responsive polymeric materials have shown great potential for efficient drug delivery and targeted treatment in various biomedical applications, including tumor therapy and disruption of the blood-brain barrier. Future research directions for the development of these smart materials are also discussed to facilitate clinical translation.
Ultrasound-responsive polymeric materials have received a tremendous amount of attention from scientists for several decades. Compared to other stimuli-responsive materials (such as UV-, thermal-, and pH-responsive materials), these smart materials are more applicable since they allow more efficient drug delivery and targeted treatment by fairly non-invasive means. This review describes the recent advances of such ultrasound-responsive polymer-based drug delivery systems and illustrates various applications. More specifically, the mechanism of ultrasound-induced drug delivery, typical formulations, and biomedical applications (tumor therapy, disruption of blood-brain barrier, fighting infectious diseases, transdermal drug delivery, and enhanced thrombolysis) are summarized. Finally, a perspective on the future research directions for the development of ultrasound-responsive polymeric materials to facilitate a clinical translation is given.
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