Journal
ARCHIVES OF OSTEOPOROSIS
Volume 16, Issue 1, Pages -Publisher
SPRINGER LONDON LTD
DOI: 10.1007/s11657-021-00931-8
Keywords
FRAX; Intervention threshold; India; Fracture probability; Osteoporosis
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The study derived and validated population-specific intervention thresholds for treatment of osteoporosis in India using the FRAX (R) model, even without bone mineral density measurement. The thresholds were found to be valid in 98.7% of patients in the validation cohort, demonstrating the efficacy of using these thresholds to avoid overtreatment.
Using the FRAX (R) model for India, thresholds for osteoporosis evaluation and treatment without bone mineral density measurement were derived and were validated in a cohort of 300 patients. We suggest the use of this newer age and ethnic-specific FRAX (R)-derived thresholds for management of osteoporosis in India. Purpose Our study aimed to formulate population-specific intervention thresholds for treatment of osteoporosis in India which can be used even without dual X-ray absorptiometry (DXA). Methods Using the FRAX (R) model for India, thresholds for different age groups for men and women were calculated without bone mineral density (BMD) measurement. The lower assessment threshold (LAT) was based on the 10-year probability of a major osteoporosis fracture (MOF) or hip fracture (HF) equivalent to patients without clinical risk factors. The intervention threshold (IT) was based on the 10-year probability equivalent to patients with fracture. The upper assessment threshold (UAT) was set at 1.2 times the IT. Probability-based thresholds for no intervention (LAT), treatment initiation (UAT) and BMD assessment (between LAT and UAT) were derived. The thresholds were validated in a cohort of 300 patients who were referred for BMD testing. Results Graphs for age, gender, BMI and ethnic-specific LAT, IT and UAT for MOF and HF are derived. In the validation cohort, BMD testing to initiate/defer treatment was required in only 32.3% patients. The intervention thresholds derived without BMD testing were valid in 98.7% patients. Use of National Osteoporosis Foundation (NOF) guidelines would have resulted in overtreatment in 56/300 (18.6%) patients. Conclusion We suggest the use of this newer age and ethnic-specific FRAX (R)-derived thresholds for management of osteoporosis. Adopting these cut-offs will ensure that those requiring osteoporosis treatment will not be denied of it just because of lack of a DXA machine and will also help avoid overtreatment.
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