Journal
APPLIED SCIENCES-BASEL
Volume 11, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/app11104519
Keywords
dry eye; dry eye disease; essential fatty acids; ocular surface; omega-3; polyunsaturated fatty acids
Categories
Funding
- Bumsuk Academic Research Fund
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Dry eye disease is a common condition that can have adverse effects on the physical, functional, and psychological quality of life. Treatment strategies aimed at interrupting the inflammatory cycle and alleviating ocular surface inflammation, such as anti-inflammatory therapies, have shown improvements in signs and symptoms. Further studies are needed to establish treatment guidelines.
Dry eye disease (DED) is a common disease, and have an adverse effect the physical, functional, and psychological quality of life. It is a multifactorial disorder characterized by the loss of tear film homeostasis, in which self-perpetuating vicious cycle leads to deterioration of function and inflammation of the lacrimal functional unit. Hence, treatment strategies should be aimed at the interruption of the vicious inflammatory cycle and alleviation of ocular surface inflammation. Anti-inflammatory therapies have been shown to improve the signs and symptoms of the disease. Evidence indicates that polyunsaturated fatty acids (PUFAs) may contribute to reinforcement of innate anti-inflammatory mechanisms, and systemic and topical administration of PUFAs may help modulate ocular surface inflammation. In the present review, the authors will introduce the results of clinical and experimental studies to elucidate the mechanism, efficacy, and safety of systemic and topical supplementation with PUFAs as an alternative therapeutic strategy for DED. This review will also include discussion regarding current perspectives, including evidence-based recommendations and possible side effects of PUFAs supplementation. The review of the literature suggests that PUFAs supplementation can be a viable option for the treatment of DED, although further studies are needed for establishment of treatment guidelines.
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