Journal
APPLIED SCIENCES-BASEL
Volume 11, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/app11104325
Keywords
methanolic extract; immunological parameters; immunostimulant; aquaculture; fish mortality
Categories
Funding
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT, and Future Planning [2016R1E1A1A01940995]
- Cooperative Research Program for Agriculture Science and Technology Development, Rural Development Administration, Republic of Korea [PJ014297]
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The study evaluated the effects of a methanol extract from Chaetomorpha aerea on immune responses and infection resistance in Labeo rohita, finding that all doses of the extract enhanced immune parameters and protected against infection, with the 50 mg/kg dose being most effective. This suggests that the extract may serve as a potential prophylactic agent against bacterial infections in finfish.
The current study evaluated the effects of a methanol extract from Chaetomorpha aerea (a green alga) on non-specific immune responses and resistance against Edwardsiella tarda infection in Labeo rohita. Different doses of the extract (5, 50 and 500 mg/kg of body weight) were injected into the fish intraperitoneally while a control group was injected with 0.2 mL of sterile physiological salt solution. Variations in several immunostimulatory parameters (i.e., neutrophil, serum lysozyme, myeloperoxidase, serum antiprotease, and ceruloplasmin activity), reactive oxygen species (ROS) and reactive nitrogen species (RNS) were assessed after 7, 14, 21, and 28 days of post stimulation. E. tarda culture was injected into the fish after 28 days of post stimulation to induce infection to monitor fish mortality within 14 days. Interestingly, all doses of methanolic extract enhanced neutrophil, lysozyme, and myeloperoxidase activity, ROS and RNS, while a dose of 50 mg/kg was the most effective. Fish injected with this optimal dose were also protected against infection with virulent strain of E. tarda. The results of the study suggest that C. aerea extract is a potential prophylactic agent against bacterial infections in finfish.
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