Journal
APPLIED SCIENCES-BASEL
Volume 11, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/app11093878
Keywords
antioxidant enzymes; pharmaceutical residues; pesticides; detergents; integrative indexes
Categories
Funding
- Fundacao para a Ciencia e a Tecnologia (FCT) [PTDC/MAR-EST/3048/2014, PTDC/CTAAMB/30056/2017, UIDB/04292/2020, UID/MULTI/04046/2019]
- Integrated Programme of SRTD SmartBioR [Centro-01-0145-FEDER000018]
- Centro 2020 program
- Portugal 2020
- European Union, through the European Regional Development Fund
- [CEECIND/00511/2017]
- [DL57/2016/CP1479/CT0024]
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The study evaluated three indexes for their sensitivity in revealing toxically induced stress patterns in cells of the diatom Phaeodactylum tricornutum under contaminant exposure, with the integrated biomarker response index (IBR) excelling for statistically significant dose-response patterns for four out of the five tested compounds.
Featured Application Evaluation of oxidative stress indexes for ecotoxicological evaluation of marine diatoms exposed to emerging contaminants. Worldwide anthropogenic activities result in the production and release of potentially damaging toxic pollutants into ecosystems, thereby jeopardizing their health and continuity. Research studies and biomonitoring programs attend to this emerging problematic by applying and developing statistically relevant indexes that integrate complex biomarker response data to provide a holistic approach, reflecting toxically induced alterations at the organism or population level. Ultimately, indexes allow simple result communications, enhancing policy makers understanding, and contributing to better resource and environmental managing policies. In this study three indexes, the integrated biomarker response index (IBR), the bioeffects assessment index (BAI) and principal components analysis (PCA), were evaluated for their sensitivity in revealing toxically induced stress patterns in cells of the diatom Phaeodactylum tricornutum under contaminant exposure. The set of biomarkers selected for index construction comprised the anti-oxidant enzymes APX, CAT and SOD, and the lipid peroxidation marker TBARS. Several significant correlations with the applied concentration gradients were noticed for all indexes, although IBR excelled for its reliability in delivering statistically significant dose-response patterns for four out of the five tested compounds.
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