3.8 Article

Systematic Approach to DNA Aptamer Design Using Amino Acid-Nucleic Acid Hybrids (ANHs) Targeting Thrombin

Related references

Note: Only part of the references are listed.
Article Chemistry, Medicinal

Improving Thermodynamic Stability and Anticoagulant Activity of a Thrombin Binding Aptamer by Incorporation of 8-trifluoromethyl-2′-deoxyguanosine

Hong-Liang Bao et al.

Summary: In this study, the incorporation of 8-trifluoromethyl-2'-deoxyguanosine ((F)G) into a thrombin binding aptamer (TBA) significantly increased the melting temperature and anticoagulant activity of the TBA sequence, demonstrating that (F)G is a powerful nucleoside derivative.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Medicine, Research & Experimental

Expanding the recognition interface of the thrombin-binding aptamer HD1 through modification of residues T3 and T12

Igor Smirnov et al.

Summary: The study investigates the enhancement of recognition interface between thrombin-binding aptamer HD1 (TBA) and thrombin by adding chemically modified side chains to selected nucleotide residues. The modified variants showed increased affinity and anticoagulant activity, with crystal structures revealing the importance of non-equivalent binding modes in determining affinity characteristics. This approach of extending the recognition surface between protein and modified aptamers holds promise for improving aptamer ligand characteristics.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

Review Biochemistry & Molecular Biology

Therapeutic applications of AS1411 aptamer, an update review

Rezvan Yazdian-Robati et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Article Chemistry, Multidisciplinary

Histidine-conjugated DNA as a biomolecular depot for metal ions

Soyoung Park et al.

RSC ADVANCES (2020)

Review Biochemistry & Molecular Biology

G-Quadruplex-Forming Aptamers-Characteristics, Applications, and Perspectives

Carolina Roxo et al.

MOLECULES (2019)

Article Chemistry, Organic

Modular DNA-based hybrid catalysts as a toolbox for enantioselective hydration of α,β-unsaturated ketones

Ji Hye Yum et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2019)

Article Medicine, Research & Experimental

Thermodynamic, Anticoagulant, and Antiproliferative Properties of Thrombin Binding Aptamer Containing Novel UNA Derivative

Weronika Kotkowiak et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2018)

Article Chemistry, Multidisciplinary

Identification of a new serine protease from polychaeta, Marphysa sanguinea, for its thrombolytic and anticoagulant activity

Seung Ju Yeon et al.

KOREAN JOURNAL OF CHEMICAL ENGINEERING (2017)

Article Biochemistry & Molecular Biology

Mapping the affinity landscape of Thrombin-binding aptamers on 2′F-ANA/DNA chimeric G-Quadruplex microarrays

Jory Lietard et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Chemistry, Analytical

Aptamer carbon nanodot sandwich used for fluorescent detection of protein

Bailu Xu et al.

ANALYST (2012)

Article Pharmacology & Pharmacy

G-quadruplex DNA Aptamers and their Ligands: Structure, Function and Application

W. O. Tucker et al.

CURRENT PHARMACEUTICAL DESIGN (2012)

Article Biochemistry & Molecular Biology

Loop residues of thrombin-binding DNA aptamer impact G-quadruplex stability and thrombin binding

Satoru Nagatoishi et al.

BIOCHIMIE (2011)

Article Biochemistry & Molecular Biology

Improving the Stability of Aptamers by Chemical Modification

R. E. Wang et al.

CURRENT MEDICINAL CHEMISTRY (2011)

Article Nanoscience & Nanotechnology

Aptamer conjugated magnetic nanoparticles as nanosurgeons

Baiju G. Nair et al.

NANOTECHNOLOGY (2010)

Article Biochemistry & Molecular Biology

In vivo selection of tumor-targeting RNA motifs

Jing Mi et al.

NATURE CHEMICAL BIOLOGY (2010)

Review Biotechnology & Applied Microbiology

Aptamers as therapeutics

Anthony D. Keefe et al.

NATURE REVIEWS DRUG DISCOVERY (2010)

Review Chemistry, Multidisciplinary

The Chemical Biology of Aptamers

Guenter Mayer

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)

Review Chemistry, Multidisciplinary

Functional Nucleic Acid Sensors

Juewen Liu et al.

CHEMICAL REVIEWS (2009)

Article Biochemistry & Molecular Biology

G-quadruplex induced stabilization by 2'-deoxy-2'-fluoro-D-arabinonucleic acids (2'F-ANA)

Chang Geng Peng et al.

NUCLEIC ACIDS RESEARCH (2007)

Article Chemistry, Analytical

Selection and analytical applications of aptamers

Camille L. A. Hamula et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2006)

Review Biochemistry & Molecular Biology

Aptamer therapeutics advance

Jennifer F. Lee et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2006)

Article Hematology

Molecular recognition mechanisms of thrombin

JA Huntington

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2005)

Article Chemistry, Analytical

Aptamer-based ATP assay using a luminescent light switching complex

J Wang et al.

ANALYTICAL CHEMISTRY (2005)

Article Multidisciplinary Sciences

DNA in a material world

NC Seeman

NATURE (2003)