Journal
NANOMATERIALS
Volume 11, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/nano11051103
Keywords
nanotubes; nano-FTIR; DNA
Categories
Funding
- BRIC INAIL project [ID52]
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The use of halloysite nanotubes as a nanostructured clay for DNA carriers has constraints, but super-resolved infrared spectroscopy proves to be an effective tool for evaluating immobilization processes in drug delivery and gene transfer. DNA molecules undergo significant structural modifications when loaded onto halloysite nanotubes, which have surface properties conducive to the selective loading of biomolecules.
The growing demand for innovative means in biomedical, therapeutic and diagnostic sciences has led to the development of nanomedicine. In this context, naturally occurring tubular nanostructures composed of rolled sheets of alumino-silicates, known as halloysite nanotubes, have found wide application. Halloysite nanotubes indeed have surface properties that favor the selective loading of biomolecules. Here, we present the first, to our knowledge, structural study of DNA-decorated halloysite nanotubes, carried out with nanometric spatially-resolved infrared spectroscopy. Single nanotube absorption measurements indicate a partial covering of halloysite by DNA molecules, which show significant structural modifications taking place upon loading. The present study highlights the constraints for the use of nanostructured clays as DNA carriers and demonstrates the power of super-resolved infrared spectroscopy as an effective and versatile tool for the evaluation of immobilization processes in the context of drug delivery and gene transfer.
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