Journal
NANOMATERIALS
Volume 11, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/nano11051065
Keywords
esophageal squamous cell carcinoma; transient photocurrent; photoelectrochemical biosensor; glutathione
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Funding
- Ministry of Science and Technology, The Republic of China [MOST 105-2923-E-194-003-MY3, 108-2823-8-194-002, 109-2622-8-194-001-TE1, 109-2622-8-194-007]
- Advanced Institute of Manufacturing with High-tech Innovations (AIM-HI) from The Featured Areas Research Center Program within Ministry of Education (MOE)
- Center for Innovative Research on Aging Society (CIRAS) from The Featured Areas Research Center Program within Ministry of Education (MOE)
- Ditmanson Medical Foundation Chia-Yi Christian Hospital Research Program
- Kaohsiung Armed Forces General Hospital research project in Taiwan [109-027]
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P-type and N-type photoelectrochemical biosensors were established in the laboratory to discuss the correlation between characteristic substances and photoactive material properties through the photogenerated charge carrier transport mechanism. Results showed that smaller photocurrent was measured in cases with advanced cancer stages, and glutathione and glutathione disulfide carry out redox reactions during carrier separation, changing the photocurrent.
P-type and N-type photoelectrochemical (PEC) biosensors were established in the laboratory to discuss the correlation between characteristic substances and photoactive material properties through the photogenerated charge carrier transport mechanism. Four types of human esophageal cancer cells (ECCs) were analyzed without requiring additional bias voltage. Photoelectrical characteristics were examined by scanning electron microscopy (SEM), X-ray diffraction (XRD), UV-vis reflectance spectroscopy, and photocurrent response analyses. Results showed that smaller photocurrent was measured in cases with advanced cancer stages. Glutathione (L-glutathione reduced, GSH) and Glutathione disulfide (GSSG) in cancer cells carry out redox reactions during carrier separation, which changes the photocurrent. The sensor can identify ECC stages with a certain level of photoelectrochemical response. The detection error can be optimized by adjusting the number of cells, and the detection time of about 5 min allowed repeated measurement.
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