Journal
NANOMATERIALS
Volume 11, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/nano11040886
Keywords
quasi-crystals; nano-biosensing; SERS; nanocavities; bacteria
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Funding
- Progetto FESR P.O.R. Campania 2007-2013-Bando sportello dell'innovazione-progetti di trasferimento tecnologico cooperativi e di prima industrializzazione per le imprese innovative ad alto potenziale, dal Titolo: Kit for Brucella Abortus e B. Melitensis na [CUP_B52I15004170002]
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This study discovered a new strategy for detecting Brucella using SERS nano-biosensing technology, which can identify the pathogen in milk and has the potential for on-site and in-food detection.
Brucella is a foodborne pathogen globally affecting both the economy and healthcare. Surface Enhanced Raman Spectroscopy (SERS) nano-biosensing can be a promising strategy for its detection. We combined high-performance quasi-crystal patterned nanocavities for Raman enhancement with the use of covalently immobilized Tbilisi bacteriophages as high-performing bio-receptors. We coupled our efficient SERS nano-biosensor to a Raman system to develop an on-field phage-based bio-sensing platform capable of monitoring the target bacteria. The developed biosensor allowed us to identify Brucella abortus in milk by our portable SERS device. Upon bacterial capture from samples (10(4) cells), a signal related to the pathogen recognition was observed, proving the concrete applicability of our system for on-site and in-food detection.
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