Journal
JOURNAL OF IMMUNOLOGY RESEARCH
Volume 2021, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2021/6647122
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Funding
- PhD Start-up Fund of Guangdong Medical University [B2019016]
- Administration of Traditional Chinese Medicine of Guangdong Province [20201180, 20211223]
- Science and Technology Special Project of Zhanjiang [2019A01009]
- Natural Science Foundation of Guangdong Province [2016B030309002]
- Basic and Applied Basic Research Program of Guangdong Province [2019A1515110201]
- GDNRC [[2020]038]
- Fund of Southern Marine Science and Engineering Guangdong Laboratory (Zhanjiang) [ZJW-2019-007]
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The study found that in lung adenocarcinoma, patients with lower levels of SHMT2 expression have a better prognosis, and SHMT2 is an independent prognostic factor in LUAD, highly associated with different types of immune cell infiltration.
It has attracted growing attention that the role of serine hydroxy methyl transferase 2 (SHMT2) in various types of cancers. However, the prognostic role of SHMT2 in lung adenocarcinoma (LUAD) and its relationship with immune cell infiltration is not clear. In this study, the information of mRNA expression and clinic data in LUAD were, respectively, downloaded from the GEO and TCGA database. We conducted a biological analysis to select the signature gene SHMT2. Online databases including Oncomine, GEPIA, TISIDB, TIMER, and HPA were applied to analyze the characterization of SHMT2 expression, prognosis, and the correlation with immune infiltration in LUAD. The mRNA expression and protein expression of SHMT2 in LUAD tissues were higher than in normal tissue. A Kaplan-Meier analysis showed that patients with lower expression level of SHMT2 had a better overall survival rate. Multivariate analysis and the Cox proportional hazard regression model revealed that SHMT2 expression was an independent prognostic factor in patients with LUAD. Meanwhile, the gene SHMT2 was highly associated with tumor-infiltrating lymphocytes in LUAD. These results suggest that the SHMT2 gene is a promising candidate as a potential prognostic biomarker and highly associated with different types of immune cell infiltration in LUAD.
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