Journal
FRONTIERS IN PHYSIOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2021.627837
Keywords
reactive oxygen species; mitochondria; oxidative stress; chronic kidney disease; kidney
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Mitochondrial reactive oxygen species (mtROS) and oxidative stress (OS) result in oxidative damage to cellular components such as lipids, DNA, and proteins, contributing to kidney damage and the progression of chronic kidney disease (CKD).
Mitochondria are known to generate approximately 90% of cellular reactive oxygen species (ROS). The imbalance between mitochondrial reactive oxygen species (mtROS) production and removal due to overproduction of ROS and/or decreased antioxidants defense activity results in oxidative stress (OS), which leads to oxidative damage that affects several cellular components such as lipids, DNA, and proteins. Since the kidney is a highly energetic organ, it is more vulnerable to damage caused by OS and thus its contribution to the development and progression of chronic kidney disease (CKD). This article aims to review the contribution of mtROS and OS to CKD progression and kidney function deterioration.
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