Journal
FRONTIERS IN PHARMACOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2021.593434
Keywords
HIV; osteoporosis; fracture; overall mortality; Chinese herbal medicine; network analysis
Categories
Funding
- China Medical University [CMU109-S-18, CMU109-S-27, CMU109-MF-41, CMU109-MF-126]
- China Medical University Hospital [DMR-110-134, DMR-110-152]
- Ministry of Science and Technology, Taiwan [MOST 108-2314-B-039-044MY3, MOST 109-2320-B-039-035-MY3, MOST 109-2410H-039-002]
Ask authors/readers for more resources
A nationwide study in Taiwan evaluated the effect of Chinese herbal medicine on overall mortality in HIV patients with osteoporosis or fractures, showing that CHM as an additional treatment significantly improves patients' survival rates. The study found that CHM users had a lower mortality rate and higher survival compared to non-users, with a main cluster of strongly related CHM combinations identified through network analysis.
The survival of patients with HIV has greatly improved, due to Anti-Retroviral Therapy (ART). However, long-term HIV survivors often develop serious bone abnormalities, possibly due to the interplay of osteoblasts, osteoclasts, HIV ad ART. We evaluated in a nation-wide study in Taiwan the effect of Chinese herbal medicine (CHM) on overall mortality in HIV patients with osteoporosis or fractures. Enrollment period was between 1998 and 2011. Patients with osteoporosis or fractures before the HIV infection, and those with less than 14 days CHM use, were excluded. This left 498 patients, 160 CHM users, 338 without CHM. Univariate Kaplan-Meier and multivariate Cox regression analysis were used to compare the overall mortality in these 2 groups. Due to the nature of Chinese medicine, CHMs inevitably varied. We therefore also used rule mining and network analysis to determine which major CHM clusters were prescribed to the patients. CHM users had a much Lower mortality (hazard ratio (HR) = 0.43, 95% confidence interval (CI): 0.24-0.77, p < 0.005) and higher survival (p = 0.004, log-rank test). Although the CHMs greatly varied, network analysis identified one main cluster of strongly related CHM combinations (Chuan-Xiong-Cha-Tiao-San (CXCTS), Gan-Cao (GC; Glycyrrhiza uralensis Fisch.), Liu-He-Tang (LHT), Huang-Qin-Tang (HQT), Jia-Wei-Ping-Wei-San (JWPWS), and Dang-Gui-Long-Hui-Wan (DGLHuiW)). CHM as an additional treatment strongly improves overall survival in HIV-infected patients with osteoporosis and fractures.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available