Journal
FRONTIERS IN PHARMACOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2021.655989
Keywords
purinergic receptors; food intake; metabolic homeostasis; orexigen and anorexigen neurons; obesity
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Funding
- Italian Ministry of Education, University and Research (MIUR)
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This review discusses the molecular mechanisms leading to changes in feeding behavior within hypothalamic neurons following purinergic receptor activation, emphasizes the importance of purinergic signaling in metabolic homeostasis, and explores the possibility of targeting its receptors for therapeutic purposes.
The purinergic signalling has a well-established role in the regulation of energy homeostasis, but there is growing evidence of its implication in the control of food intake. In this review, we provide an integrative view of the molecular mechanisms leading to changes in feeding behaviour within hypothalamic neurons following purinergic receptor activation. We also highlight the importance of purinergic signalling in metabolic homeostasis and the possibility of targeting its receptors for therapeutic purposes.
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