4.7 Article

The Heat Sensing Trpv1 Receptor Is Not a Viable Anticonvulsant Drug Target in the Scn1a +/- Mouse Model of Dravet Syndrome

Related references

Note: Only part of the references are listed.
Article Pharmacology & Pharmacy

Evaluation of the Possible Anticonvulsant Effect of Δ9-Tetrahydrocannabinolic Acid in Murine Seizure Models

Melissa J. Benson et al.

Summary: Delta(9)-tetrahydrocannabinolic acid (Delta(9)-THCA) has variable anticonvulsant effects depending on the seizure model used and the presence of Delta(9)-THC. Its unstable nature poses challenges for further drug development. Future studies should focus on understanding the mechanisms by which combined Delta(9)-THCA and Delta(9)-THC alter seizure thresholds.

CANNABIS AND CANNABINOID RESEARCH (2022)

Article Clinical Neurology

CBD Effects on TRPVI Signaling Pathways in Cultured DRG Neurons

Uma Anand et al.

JOURNAL OF PAIN RESEARCH (2020)

Review Biochemistry & Molecular Biology

Insights into Potential Targets for Therapeutic Intervention in Epilepsy

Cecilia Zavala-Tecuapetla et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Physiology

Blocking the transient receptor potential vanilloid-1 does not reduce the exercise pressor reflex in healthy rats

Guillaume P. Ducrocq et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2019)

Article Clinical Neurology

Cacna1g is a genetic modifier of epilepsy in a mouse model of Dravet syndrome

Jeffrey D. Calhoun et al.

EPILEPSIA (2017)

Article Medicine, General & Internal

Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome

Orrin Devinsky et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Clinical Neurology

Screening of conventional anticonvulsants in a genetic mouse model of epilepsy

Nicole A. Hawkins et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2017)

Article Multidisciplinary Sciences

Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome

Lyndsey L. Anderson et al.

SCIENTIFIC REPORTS (2017)

Article Clinical Neurology

Hlf is a genetic modifier of epilepsy caused by voltage-gated sodium channel mutations

Nicole A. Hawkins et al.

EPILEPSY RESEARCH (2016)

Article Clinical Neurology

TRPV1 deletion exacerbates hyperthermic seizures in an age-dependent manner in mice

Karlene T. Barrett et al.

EPILEPSY RESEARCH (2016)

Article Biochemistry & Molecular Biology

GABA Blocks Pathological but Not Acute TRPV1 Pain Signals

Christina Hanack et al.

Article Neurosciences

Plasticity in striatopallidal projection neurons mediates the acquisition of habitual actions

Qiang Shan et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2015)

Article Clinical Neurology

α-Spinasterol, a TRPV1 receptor antagonist, elevates the seizure threshold in three acute seizure tests in mice

Katarzyna Socala et al.

JOURNAL OF NEURAL TRANSMISSION (2015)

Article Neurosciences

Interference of TRPV1 function altered the susceptibility of PTZ-induced seizures

Yun-Fang Jia et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2015)

Review Clinical Neurology

Dravet syndrome-From epileptic encephalopathy to channelopathy

Andreas Brunklaus et al.

EPILEPSIA (2014)

Article Behavioral Sciences

Mapping genetic modifiers of survival in a mouse model of Dravet syndrome

A. R. Miller et al.

GENES BRAIN AND BEHAVIOR (2014)

Article Pharmacology & Pharmacy

Piperine exerts anti-seizure effects via the TRPV1 receptor in mice

Chang-Yuan Chen et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2013)

Article Biochemistry & Molecular Biology

Increased Expression of TRPV1 in the Cortex and Hippocampus from Patients with Mesial Temporal Lobe Epilepsy

Fei-Ji Sun et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2013)

Article Pharmacology & Pharmacy

Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes

Luciano De Petrocellis et al.

BRITISH JOURNAL OF PHARMACOLOGY (2011)

Article Clinical Neurology

The genetics of Dravet syndrome

Carla Marini et al.

EPILEPSIA (2011)

Article Neurosciences

Thermally Active TRPV1 Tonically Drives Central Spontaneous Glutamate Release

Kiyomitsu Shoudai et al.

JOURNAL OF NEUROSCIENCE (2010)

Article Pharmacology & Pharmacy

Analgesic potential of TRPV1 antagonists

Philip R. Kym et al.

BIOCHEMICAL PHARMACOLOGY (2009)

Article Clinical Neurology

Clinical spectrum of SCN1A mutations

Antonio Gambardella et al.

EPILEPSIA (2009)

Article Gastroenterology & Hepatology

Essential role for TRPV1 in stress-induced (mast cell-dependent) colonic hypersensitivity in maternally separated rats

R. M. van den Wijngaard et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2009)

Article Chemistry, Medicinal

Discovery of SB-705498: A potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development

HK Rami et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)

Article Behavioral Sciences

Food intake, water intake, and drinking spout side preference of 28 mouse strains

AA Bachmanov et al.

BEHAVIOR GENETICS (2002)

Review Neurosciences

The vanilloid receptor: A molecular gateway to the pain pathway

MJ Caterina et al.

ANNUAL REVIEW OF NEUROSCIENCE (2001)

Article Multidisciplinary Sciences

Impaired nociception and pain sensation in mice lacking the capsaicin receptor

MJ Caterina et al.

SCIENCE (2000)